Abstract
Background
The impact of dietary phosphorus (P) excess, especially on renal and cardiovascular health, has been investigated in several species, but little is known in dogs.
Objective
The aim of this study was to examine effects of different P sources on concentration and postprandial kinetics of selected parameters of P homeostasis in dogs.
Methods
Eight beagles received one control diet (P 0.5% dry matter [DM]) and three high P diets (poultry meal, NaH2PO4, and KH2PO4; P 1.7% DM) for 18d. Urine samples were collected pre- and postprandially while faeces were collected quantitatively for 5d and analysed for minerals. On day 18, blood was sampled 1h pre- and 0.5, 1, 1.5, 2, 3, 5 and 7h postprandially.
Results
Pi (KH2PO4, NaH2PO4) but not organic P caused an increased apparent P digestibility and significantly influenced kinetics of serum FGF23, parathyroid hormone, P, CrossLaps and bonespecific alkaline phosphatase, demonstrating a disrupted calcium (Ca) and P homeostasis with potential harm for renal, cardiovascular and skeletal health.
Conclusions
Results of feeding Pi to dogs indicate distinct disturbances of Ca and P metabolism, in contrast to organic sources. The use of Pi in food can therefore not be considered as safe. Further research, especially on dose and long-term effects, is warranted.
Publisher
Public Library of Science (PLoS)
Reference134 articles.
1. KEGG, editor. Kyoto Encyclopedia of Genes and Genomes; September 29th 2019. https://www.genome.jp/dbget-bin/www_bfind_sub?mode=bfind&max_hit=1000&locale=en&serv=kegg&dbkey=reaction&keywords=phosphate&page=1.; 2019.
2. Organic and inorganic phosphorus and its management in chronic kidney disease;N Noori;Iranian Journal of Kidney Disease,2010
3. Sodium- and phosphorus-based food additives: persistent but surmountable hurdles in the management of nutrition in chronic kidney disease;OM Gutiérrez;Adv Chronic Kidney Dis,2013
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