A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties

Author:

Nyborg Andrew C.,Ward Chris,Zacco Anna,Chacko Benoy,Grinberg Luba,Geoghegan James C.,Bean Ryan,Wendeler Michaela,Bartnik Frank,O’Connor Ellen,Gruia Flaviu,Iyer Vidyashankara,Feng Hui,Roy Varnika,Berge Mark,Miner Jeffrey N.,Wilson David M.,Zhou Dongmei,Nicholson Simone,Wilker Clynn,Wu Chi Y.,Wilson Susan,Jermutus Lutz,Wu Herren,Owen David A.,Osbourn Jane,Coats Steven,Baca Manuel

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference50 articles.

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3. Spectroscopic characterization of intermediates in the urate oxidase reaction;K Kahn;Biochemistry,1998

4. Evolutionary history and metabolic insights of ancient mammalian uricases;JT Kratzer;Proceedings of the National Academy of Sciences of the United States of America,2014

5. Uricase protein sequences: conserved during vertebrate evolution but absent in humans;A Varela-Echavarria;FASEB journal: official publication of the Federation of American Societies for Experimental Biology,1988

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