Down-Regulation of CXCL12/CXCR4 Expression Alleviates Ischemia-Reperfusion-Induced Inflammatory Pain via Inhibiting Glial TLR4 Activation in the Spinal Cord

Author:

Li Xiao-Qian,Zhang Zai-Li,Tan Wen-Fei,Sun Xi-Jia,Ma Hong

Funder

Doctoral Fund of the Ministry of Education of China

Science and Technology Program of Liaoning

Natural Science Foundation of Liaoning Province

National Natural Science Foundation of China

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference30 articles.

1. Development and treatments of inflammatory cells and cytokines in spinal cord ischemia-reperfusion injury;P Zhu;Mediators Inflamm,2013

2. CD200R1 agonist attenuates glial activation, inflammatory reactions, and hypersensitivity immediately after its intrathecal application in a rat neuropathic pain model;M Hernangómez;J Neuroinflammation,2016

3. Toll-like receptors in central nervous system injury and disease: a focus on the spinal cord;A Heiman;Brain Behav Immun,2014

4. Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice;JA Stokes;J Neuroinflammation,2013

5. Analgesic effect of TAK-242 on neuropathic pain in rats;Y Zhao;Int J Clin Exp Med,2015

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