Amino acid substitutions at the HIV-1 transframe region significantly impair virus infectivity

Author:

Yu Fu-Hsien,Huang Kuo-Jung,Wang Chin-TienORCID

Abstract

A transframe region within HIV-1 Gag-Pol (referred to as p6* or p6pol), directly linked to the protease (PR) N-terminus, plays a pivotal role in modulating PR activation. To identify specific p6* residues involved in PR activation, we created a series of p6* mutants by making substitutions for conserved p6* residues. Our results indicate that some p6* mutants were defective in terms of virus infectivity, despite displaying a wild-type virus particle processing pattern. Mutations at p6* F8 reduced virus infectivity associated with insufficient virus processing, due in part to impaired PR maturation and RT packaging. Our data strongly suggest that conserved Phe (F) residues at position 8 of p6* are involved in the PR maturation process.

Funder

Ministry of Science and Technology, Taiwan

Taipei Veterans General Hospital

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

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