Abstract
We propose a model of cancer initiation and progression where tumor growth is modulated by an evolutionary coordination game. Evolutionary games of cancer are widely used to model frequency-dependent cell interactions with the most studied games being the Prisoner’s Dilemma and public goods games. Coordination games, by their more obscure and less evocative nature, are left understudied, despite the fact that, as we argue, they offer great potential in understanding and treating cancer. In this paper we present the conditions under which coordination games between cancer cells evolve, we propose aspects of cancer that can be modeled as results of coordination games, and explore the ways through which coordination games of cancer can be exploited for therapy.
Publisher
Public Library of Science (PLoS)
Reference40 articles.
1. Game-theory models of interactions between tumour cells;I Tomlinson;European Journal of Cancer,1997
2. Application of quantitative models from population biology and evolutionary game theory to tumor therapeutic strategies;RA Gatenby;Molecular cancer therapeutics,2003
3. Evolutionary dynamics in cancer therapy;JJ Cunningham;Molecular pharmaceutics,2011
4. Why Darwin would have loved evolutionary game theory;JS Brown;Proceedings of the Royal Society B: Biological Sciences,2016
5. Prisoner’s dilemma in cancer metabolism;I Kareva;PloS one,2011
Cited by
12 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献