Abstract
Objective
To end the AIDS epidemic by 2030, despite the increasing poverty and inequalities, policies should be designed to deal with population heterogeneity and environmental changes. Bottom-up designs, such as the Agent-Based Model (ABM), can model these features, dealing with such complexity. HIV/AIDS has a complex dynamic of structural factors, risk behaviors, biomedical characteristics and interventions. All embedded in unequal, stigmatized and heterogeneous social structure. To understand how ABMs can model this complexity, we performed a scoping review of HIV applications, highlighting their potentialities.
Methods
We searched on PubMed, Web of Science, and Scopus repositories following the PRISMA extension for scoping reviews. Our inclusion criteria were HIV/AIDS studies with an ABM application. We identified the main articles using a local co-citation analysis and categorized the overall literature aims, (sub)populations, regions, and if the papers declared the use of ODD protocol and limitations.
Results
We found 154 articles. We identified eleven main papers, and discussed them using the overall category results. Most studies model Transmission Dynamics (37/154), about Men who have sex with Men (MSM) (41/154), or individuals living in the US or South Africa (84/154). Recent studies applied ABM to model PrEP interventions (17/154) and Racial Disparities (12/154). Only six papers declared the use of ODD Protocol (6/154), and 34/154 didn’t mention the study limitations.
Conclusions
While ABM is among the most sophisticated techniques available to model HIV/AIDS complexity. Their applications are still restricted to some realities. However, researchers are challenged to think about social structure due model characteristics, the inclusion of these features is still restricted to case-specific. Data and computational power availability can enhance this feature providing insightful results.
Funder
Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases
Publisher
Public Library of Science (PLoS)
Reference66 articles.
1. UNAIDS U. UNAIDS terminology guidelines. 2011.
2. Social Determinants of Health—MeSH—NCBI. [cited 12 Jan 2022]. Available: https://www.ncbi.nlm.nih.gov/mesh/?term=social+determinants+of+health
3. Modeling the Impact of Social Determinants of Health on HIV;JW Hogan;AIDS Behav,2021
4. Dangerous inequalities: World AIDS Day report 2022. 2022.
5. Fast-Track—Ending the AIDS epidemic by 2030. [cited 12 Jan 2022]. Available: https://www.unaids.org/en/resources/documents/2014/JC2686_WAD2014report