Isoform Switch of Pyruvate Kinase M1 Indeed Occurs but Not to Pyruvate Kinase M2 in Human Tumorigenesis

Author:

Zhan Cheng,Yan Li,Wang Lin,Ma Jun,Jiang Wei,Zhang Yongxing,Shi Yu,Wang Qun

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference49 articles.

1. Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells;S Mazurek;Int J Biochem Cell Biol,2011

2. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth;HR Christofk;Nature,2008

3. Pyruvate kinase type M2 and its role in tumor growth and spreading;S Mazurek;Semin Cancer Biol,2005

4. No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis;K Bluemlein;Oncotarget,2011

5. Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers;S Desai;Oncotarget,2013

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