Diversity and evolution of computationally predicted T cell epitopes against human respiratory syncytial virus
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Published:2023-01-10
Issue:1
Volume:19
Page:e1010360
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ISSN:1553-7358
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Container-title:PLOS Computational Biology
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language:en
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Short-container-title:PLoS Comput Biol
Author:
Chen Jiani,
Tan Swan,
Avadhanula Vasanthi,
Moise LeonardORCID,
Piedra Pedro A.,
De Groot Anne S.,
Bahl JustinORCID
Abstract
Human respiratory syncytial virus (RSV) is a major cause of lower respiratory infection. Despite more than 60 years of research, there is no licensed vaccine. While B cell response is a major focus for vaccine design, the T cell epitope profile of RSV is also important for vaccine development. Here, we computationally predicted putative T cell epitopes in the Fusion protein (F) and Glycoprotein (G) of RSV wild circulating strains by predicting Major Histocompatibility Complex (MHC) class I and class II binding affinity. We limited our inferences to conserved epitopes in both F and G proteins that have been experimentally validated. We applied multidimensional scaling (MDS) to construct T cell epitope landscapes to investigate the diversity and evolution of T cell profiles across different RSV strains. We find the RSV strains are clustered into three RSV-A groups and two RSV-B groups on this T epitope landscape. These clusters represent divergent RSV strains with potentially different immunogenic profiles. In addition, our results show a greater proportion of F protein T cell epitope content conservation among recent epidemic strains, whereas the G protein T cell epitope content was decreased. Importantly, our results suggest that RSV-A and RSV-B have different patterns of epitope drift and replacement and that RSV-B vaccines may need more frequent updates. Our study provides a novel framework to study RSV T cell epitope evolution. Understanding the patterns of T cell epitope conservation and change may be valuable for vaccine design and assessment.
Funder
Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases
Centers for Disease Control and Prevention
Publisher
Public Library of Science (PLoS)
Subject
Computational Theory and Mathematics,Cellular and Molecular Neuroscience,Genetics,Molecular Biology,Ecology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics
Reference61 articles.
1. Paramyxoviruses: Respiratory Syncytial Virus and Human Metapneumovirus: Viral Infections of Humans.;JE Crowe,2014
2. Complete genome sequences of human respiratory syncytial virus genotype a and B isolates from South Korea;MR Yun;Genome Announc,2015
3. Structure and function of respiratory syncytial virus surface glycoproteins;JS McLellan;Curr Top Microbiol Immunol,2013
4. Protective antigenic sites in respiratory syncytial virus G attachment protein outside the central conserved and cysteine noose domains.;J Lee;PLOS Pathogens,2018
5. Updated guidance for palivizumab prophylaxis among infants and young children at increased risk of hospitalization for respiratory syncytial virus infection.;Pediatrics,2014
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