Maternal emulsifier consumption programs offspring metabolic and neuropsychological health in mice

Author:

Milà-Guasch Maria,Ramírez Sara,Llana Sergio R.,Fos-Domènech Júlia,Dropmann Lea Maria,Pozo Macarena,Eyre Elena,Gómez-Valadés Alicia G.,Obri Arnaud,Haddad-Tóvolli Roberta,Claret MarcORCID

Abstract

Modern lifestyle is associated with a major consumption of ultra–processed foods (UPF) due to their practicality and palatability. The ingestion of emulsifiers, a main additive in UPFs, has been related to gut inflammation, microbiota dysbiosis, adiposity, and obesity. Maternal unbalanced nutritional habits during embryonic and perinatal stages perturb offspring’s long–term metabolic health, thus increasing obesity and associated comorbidity risk. However, whether maternal emulsifier consumption influences developmental programming in the offspring remains unknown. Here, we show that, in mice, maternal consumption of dietary emulsifiers (1% carboxymethyl cellulose (CMC) and 1% P80 in drinking water), during gestation and lactation, perturbs the development of hypothalamic energy balance regulation centers of the progeny, leads to metabolic impairments, cognition deficits, and induces anxiety–like traits in a sex–specific manner. Our findings support the notion that maternal consumption of emulsifiers, common additives of UPFs, causes mild metabolic and neuropsychological malprogramming in the progeny. Our data call for nutritional advice during gestation.

Funder

European Research Council

“la Caixa” Foundation

H2020 Marie Skłodowska-Curie Actions

Spanish Ministry of Science and Innovation

Instituto de Salud Carlos III

Publisher

Public Library of Science (PLoS)

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

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