Cardiac strain is lower among women with HIV in relation to monocyte activation

Author:

Toribio Mabel,Awadalla MagidORCID,Drobni Zsofia D.,Quinaglia ThiagoORCID,Wang Melissa,Durbin Claudia G.,Alagpulinsa David A.,Fourman Lindsay T.ORCID,Suero-Abreu Giselle AlexandraORCID,Nelson Michael D.,Stanley Takara L.,Longenecker Christopher T.ORCID,Burdo Tricia H.,Neilan Tomas G.,Zanni Markella V.ORCID

Abstract

Background Women with HIV (WWH) face heightened risks of heart failure; however, insights on immune/inflammatory pathways potentially contributing to left ventricular (LV) systolic dysfunction among WWH remain limited. Setting Massachusetts General Hospital, Boston, Massachusetts. Methods Global longitudinal strain (GLS) is a sensitive measure of LV systolic function, with lower cardiac strain predicting incident heart failure and adverse heart failure outcomes. We analyzed relationships between GLS (cardiovascular magnetic resonance imaging) and monocyte activation (flow cytometry) among 20 WWH and 14 women without HIV. Results WWH had lower GLS compared to women without HIV (WWH vs. women without HIV: 19.4±3.0 vs. 23.1±1.9%, P<0.0001). Among the whole group, HIV status was an independent predictor of lower GLS. Among WWH (but not among women without HIV), lower GLS related to a higher density of expression of HLA-DR on the surface of CD14+CD16+ monocytes (ρ = -0.45, P = 0.0475). Further, among WWH, inflammatory monocyte activation predicted lower GLS, even after controlling for CD4+ T-cell count and HIV viral load. Conclusions Additional studies among WWH are needed to examine the role of inflammatory monocyte activation in the pathogenesis of lower GLS and to determine whether targeting this immune pathway may mitigate risks of heart failure and/or adverse heart failure outcomes. Trial registration Clinical trials.gov registration: NCT02874703.

Funder

NIH/Harvard Center for AIDS Research

NIH/ National Heart, Lung, and Blood Institute

Robert Wood Johnson Foundation

National Research, Development, and Innovation Fund

NIH/National Institute of Child Health and Human Development

NIH/NHLBI

Michael and Kathryn Park Chair

Hassenfeld Scholar Award

Paul and Christina Kasolinas

A. Curt Greer and Pamela Kohlberg

NIH/NIAID

Nutrition Obesity Research Center

National Center for Research Resources

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

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