Abstract
Background
Women with HIV (WWH) face heightened risks of heart failure; however, insights on immune/inflammatory pathways potentially contributing to left ventricular (LV) systolic dysfunction among WWH remain limited.
Setting
Massachusetts General Hospital, Boston, Massachusetts.
Methods
Global longitudinal strain (GLS) is a sensitive measure of LV systolic function, with lower cardiac strain predicting incident heart failure and adverse heart failure outcomes. We analyzed relationships between GLS (cardiovascular magnetic resonance imaging) and monocyte activation (flow cytometry) among 20 WWH and 14 women without HIV.
Results
WWH had lower GLS compared to women without HIV (WWH vs. women without HIV: 19.4±3.0 vs. 23.1±1.9%, P<0.0001). Among the whole group, HIV status was an independent predictor of lower GLS. Among WWH (but not among women without HIV), lower GLS related to a higher density of expression of HLA-DR on the surface of CD14+CD16+ monocytes (ρ = -0.45, P = 0.0475). Further, among WWH, inflammatory monocyte activation predicted lower GLS, even after controlling for CD4+ T-cell count and HIV viral load.
Conclusions
Additional studies among WWH are needed to examine the role of inflammatory monocyte activation in the pathogenesis of lower GLS and to determine whether targeting this immune pathway may mitigate risks of heart failure and/or adverse heart failure outcomes.
Trial registration
Clinical trials.gov registration: NCT02874703.
Funder
NIH/Harvard Center for AIDS Research
NIH/ National Heart, Lung, and Blood Institute
Robert Wood Johnson Foundation
National Research, Development, and Innovation Fund
NIH/National Institute of Child Health and Human Development
NIH/NHLBI
Michael and Kathryn Park Chair
Hassenfeld Scholar Award
Paul and Christina Kasolinas
A. Curt Greer and Pamela Kohlberg
NIH/NIAID
Nutrition Obesity Research Center
National Center for Research Resources
Publisher
Public Library of Science (PLoS)
Cited by
1 articles.
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