Systemic Delivery of siRNA Down Regulates Brain Prion Protein and Ameliorates Neuropathology in Prion Disorder

Author:

Lehmann Sylvain,Relano-Gines Aroa,Resina Sarah,Brillaud Elsa,Casanova Danielle,Vincent Charles,Hamela Claire,Poupeau Sophie,Laffont Mathieu,Gabelle Audrey,Delaby Constance,Belondrade Maxime,Arnaud Jacques-Damien,Alvarez Maria-Teresa,Maurel Jean-Claude,Maurel Patrick,Crozet Carole

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference22 articles.

1. Human prion diseases: from kuru to variant creutzfeldt-jakob disease;B Sikorska;Subcell Biochem,2012

2. Molecular pathology, classification, and diagnosis of sporadic human prion disease variants;P Parchi;Folia Neuropathol,2012

3. Novel proteinaceous infectious particles cause scrapie;SB Prusiner;Science,1982

4. Mice devoid of PrP are resistant to scrapie;H Bueler;Cell,1993

5. No propagation of prions in mice devoid of PrP;A Sailer;Cell,1994

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