Universal varicella vaccination in Denmark: Modeling public health impact, age-shift, and cost-effectiveness

Author:

Burgess ColleenORCID,Samant Salome,leFevre ThomasORCID,Schade Larsen Carsten,Pawaskar Manjiri

Abstract

We modeled the long-term clinical and economic impact of two-dose universal varicella vaccination (UVV) strategies in Denmark using a dynamic transmission model. The cost-effectiveness of UVV was evaluated along with the impact on varicella (including age-shift) and herpes zoster burden. Six two-dose UVV strategies were compared to no vaccination, at either short (12/15 months) or medium (15/48 months) intervals. Monovalent vaccines (V-MSD or V-GSK) for the 1st dose, and either monovalent or quadrivalent vaccines (MMRV-MSD or MMRV-GSK) for the 2nd dose were considered. Compared to no vaccination, all two-dose UVV strategies reduced varicella cases by 94%-96%, hospitalizations by 93%-94%, and deaths by 91%-92% over 50 years; herpes zoster cases were also reduced by 9%. There was a decline in the total number of annual varicella cases in all age groups including adolescents and adults. All UVV strategies were cost-effective compared to no vaccination, with ICER values ranging from €18,228-€20,263/QALY (payer perspective) and €3,746-€5,937/QALY (societal perspective). The frontier analysis showed that a two-dose strategy with V-MSD (15 months) and MMRV-MSD (48 months) dominated all other strategies and was the most cost-effective. In conclusion, all modeled two-dose UVV strategies were projected to substantially reduce the clinical and economic burden of varicella disease in Denmark compared to the current no vaccination strategy, with declines in both varicella and zoster incidence for all age groups over a 50-year time horizon.

Funder

Merck Sharp & Dohme LLC

Publisher

Public Library of Science (PLoS)

Reference42 articles.

1. Varicella vaccination—the global experience.;P Wutzler;Expert Rev Vaccines.,2017

2. Varicella and herpes zoster vaccines: WHO position paper, June 2014.;Wkly Epidemiol Rec.,2014

3. European Centre for Disease Prevention and Control. Vaccine Scheduler 2020 updated December 16, 2020. Available from: https://vaccine-schedule.ecdc.europa.eu/Scheduler/ByCountry?SelectedCountryId=58&IncludeChildAgeGroup=true&IncludeChildAgeGroup=false&IncludeAdultAgeGroup=true&IncludeAdultAgeGroup=false.

4. Economic burden of varicella in Europe in the absence of universal varicella vaccination.;M Pawaskar;BMC public health.,2021

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