A Single Mutation in the PB1-F2 of H5N1 (HK/97) and 1918 Influenza A Viruses Contributes to Increased Virulence

Author:

Conenello Gina M,Zamarin Dmitriy,Perrone Lucy A,Tumpey Terrence,Palese Peter

Publisher

Public Library of Science (PLoS)

Subject

Virology,Genetics,Molecular Biology,Immunology,Microbiology,Parasitology

Reference37 articles.

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3. World Health Organization 2007 Acute respiratory infections: Influenza Available at: http://www.who.int/vaccine_research/diseases/ari/en/. Accessed 30 April 2007.

4. Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia.;Nat Med,2006

5. Distinct pathogenesis of Hong Kong-origin H5N1 viruses in mice compared to that of other highly pathogenic H5 avian influenza viruses.;J Virol,2000

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