Obsessive-compulsive disorder is characterized by decreased Pavlovian influence on instrumental behavior
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Published:2022-10-10
Issue:10
Volume:18
Page:e1009945
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ISSN:1553-7358
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Container-title:PLOS Computational Biology
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language:en
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Short-container-title:PLoS Comput Biol
Author:
Peng Ziwen,
He LuningORCID,
Wen Rongzhen,
Verguts TomORCID,
Seger Carol A.,
Chen QiORCID
Abstract
Obsessive-compulsive disorder (OCD) is characterized by uncontrollable repetitive actions thought to rely on abnormalities within fundamental instrumental learning systems. We investigated cognitive and computational mechanisms underlying Pavlovian biases on instrumental behavior in both clinical OCD patients and healthy controls using a Pavlovian-Instrumental Transfer (PIT) task. PIT is typically evidenced by increased responding in the presence of a positive (previously rewarded) Pavlovian cue, and reduced responding in the presence of a negative cue. Thirty OCD patients and thirty-one healthy controls completed the Pavlovian Instrumental Transfer test, which included instrumental training, Pavlovian training for positive, negative and neutral cues, and a PIT phase in which participants performed the instrumental task in the presence of the Pavlovian cues. Modified Rescorla-Wagner models were fitted to trial-by-trial data of participants to estimate underlying computational mechanism and quantify individual differences during training and transfer stages. Bayesian hierarchical methods were used to estimate free parameters and compare the models. Behavioral and computational results indicated a weaker Pavlovian influence on instrumental behavior in OCD patients than in HC, especially for negative Pavlovian cues. Our results contrast with the increased PIT effects reported for another set of disorders characterized by compulsivity, substance use disorders, in which PIT is enhanced. A possible reason for the reduced PIT in OCD may be impairment in using the contextual information provided by the cues to appropriately adjust behavior, especially when inhibiting responding when a negative cue is present. This study provides deeper insight into our understanding of deficits in OCD from the perspective of Pavlovian influences on instrumental behavior and may have implications for OCD treatment modalities focused on reducing compulsive behaviors.
Funder
National Natural Science Foundation of China
Ministry of Science and Technology of the People's Republic of China
Basic and Applied Basic Research Foundation of Guangdong Province
Publisher
Public Library of Science (PLoS)
Subject
Computational Theory and Mathematics,Cellular and Molecular Neuroscience,Genetics,Molecular Biology,Ecology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics
Reference65 articles.
1. Obsessive-Compulsive Disorder: Puzzles and Prospects.;TW Robbins;Neuron,2019
2. The role of habit in compulsivity.;CM Gillan;Eur Neuropsychopharmacol.,2016
3. Human pavlovian-instrumental transfer;D Talmi;J Neurosci,2008
4. Pavlovian-to-instrumental transfer in subclinical obsessive–compulsive disorder.;AM Krypotos;J Exp Psychopathol.,2020
5. The specificity of Pavlovian regulation is associated with recovery from depression.;QJM Huys;Psychol Med,2016