Nasopharyngeal colonization by Streptococcus pneumoniae in children and adults before the introduction of the 10-valent conjugate vaccine, Paraguay

Author:

Chamorro Gustavo,Kawabata AníbalORCID,Carvalho María da Gloria,Pimenta Fabiana C.,Lessa Fernanda C.,Torres Carlos,Lerea María José,León María EugeniaORCID

Abstract

Streptococcus pneumoniae is a cause of invasive diseases such as pneumonia, meningitis, and other serious infections among children and adults in Paraguay. This study was conducted to establish S. pneumoniae baseline prevalence, serotype distribution, and antibiotic resistance patterns in healthy children aged 2 to 59 months and adults ≥60 years of age prior to the introduction of PCV10 in the national childhood immunization program in Paraguay. Between April and July 2012, a total of 1444 nasopharyngeal swabs were collected, 718 from children aged 2 to 59 months and 726 from adults ≥60 years of age. The pneumococcal isolation, serotyping, and antibiotic susceptibility testing were performed using standard tests. Pneumococcal colonization prevalence was 34.1% (245/718) in children and 3.3% (24/726) in adults. The most frequent pneumococcal vaccine-types (VT) detected in the children were 6B (42/245), 19F (32/245), 14 (17/245), and 23F (20/245). Carriage prevalence with PCV10 serotypes was 50.6% (124/245) and PCV13 was 59.5% (146/245). Among colonized adults, prevalence of PCV10 and PCV13 serotypes were 29.1% (7/24) and 41.6% (10/24), respectively. Colonized children were more likely to share a bedroom, have a history of respiratory infection or pneumococcal infection compared to non-colonized children. no associations were found in adults. However, no significant associations were found in children and neither in adults. Vaccine-type pneumococcal colonization was highly prevalent in children and rare in adults in Paraguay prior to vaccine introduction, supporting the introduction of PCV10 in the country in 2012. These data will be useful to evaluate the impact of PCV introduction in the country.

Funder

Mercosur Structural Convergence Fund

Ministry of Public Health and Social Welfare

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference41 articles.

1. Status of research and development of pediatric vaccines for Streptococcus pneumoniae;MR Alderson;Vaccine,2016

2. Pneumococcal conjugate vaccines in infants and children under 5 years of age: WHO position paper–February 2019 Weekly Epidemiological Record No 8;World Health Organization,2019

3. Pneumococcal vaccines: understanding centers for disease control and prevention recommendations;M Mirsaeidi;Ann Am Thorac Socty,2014

4. Nasopharyngeal carriage and antimicrobial susceptibility pattern of Streptococcus pneumoniae among pediatric outpatients at Gondar University Hospital, North West Ethiopia;A Assefa;Pediatr Neonatol,2013

5. Pneumococcal carriage and antibiotic susceptibility patterns from two cross-sectional colonization surveys among children aged;M Kobayashi;BMC Infect Dis,2017

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