Integrated brain and plasma dual-channel metabolomics to explore the treatment effects of Alpinia oxyphyllaFructus on Alzheimer’s disease

Author:

Sun ZhiORCID,Zhang Yuanyuan,Zhang Mengya,Zhou Shengnan,Cheng Wenbo,Xue Lianping,Zhou Peipei,Li Xiaojing,Zhang Zhibo,Zuo Lihua

Abstract

Alpinia oxyphyllaFructus, called Yizhi in Chinese, is the dried fruit of Alpinia oxyphylla Miquel. It has been used in traditional Chinese medicine to treat dementia and memory defects of Alzheimer’s disease for many years. However, the underlying mechanism is still unclear. In this study, we used a rat Alzheimer’s disease model on intrahippocampal injection of aggregated Aβ1–42to study the effects ofAlpinia oxyphyllaFructus. A brain and plasma dual-channel metabolomics approach combined with multivariate statistical analysis was further performed to determine the effects ofAlpinia oxyphyllaFructus on Alzheimer’s disease animals. As a result, in the Morris water maze test,Alpinia oxyphyllaFructus had a clear ability to ameliorate the impaired learning and memory of Alzheimer’s disease rats. 11 differential biomarkers were detected in AD rats’ brains. The compounds mainly included amino acids and phospholipids; afterAlpinia oxyphyllaFructus administration, 9 regulated biomarkers were detected compared with the AD model group. In the plasma of AD rats, 29 differential biomarkers, primarily amino acids, phospholipids and fatty acids, were identified; After administration, 23 regulated biomarkers were detected. The metabolic pathways of regulated metabolites suggest thatAlpinia oxyphyllaFructus ameliorates memory and learning deficits in AD rats principally by regulating amino acid metabolism, lipids metabolism, and energy metabolism. In conclusion, our results confirm and enhance our current understanding of the therapeutic effects ofAlpinia oxyphyllaFructus on Alzheimer’s disease. Meanwhile, our work provides new insight into the potential intervention mechanism ofAlpinia oxyphyllaFructus for Alzheimer’s disease treatment.

Funder

the National Key Research and Development Program of China

Innovative Research Group Project of the National Natural Science Foundation of China

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

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