Study on the Anticancer Drug 5-Fluorouracil-Conjugated Polyaspartamide Containing Hepatocyte-Targeting Group-Reference-Cited by-同舟云学术

Study on the Anticancer Drug 5-Fluorouracil-Conjugated Polyaspartamide Containing Hepatocyte-Targeting Group

Published:2001-07 Issue:4 Volume:16 Page:277-293
ISSN:0883-9115
Container-title:Journal of Bioactive and Compatible Polymers
language:en
Short-container-title:Journal of Bioactive and Compatible Polymers

Author:

Yan Guo-Ping¹,Zhuo Ren-Xi¹,Zheng Cong-Yi²

Affiliation:

1. Laboratory of Biomedical Polymer Materials of the Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China

2. College of Life Sciences, Wuhan University, Wuhan 430072, P. R. China

Abstract

Anticancer conjugates of 5-fluorouracil (5-Fu) and polyaspartamide, containing pyridoxamine as the hepatocyte-targeting group, were synthesized and characterized. Their sustained release properties and biodistribution were evaluated. The 5-Fu was targeted to specific organs, such as the liver, and had a sustained in vitro release rate in PBS. In vitro cytotoxicity assay showed that the polymeric drugs exhibited low cytotoxicity to the human liver cells (L-02). These polymeric drugs possess high anticancer efficiencies and induced apoptosis in the human hepatic tumor cells (Bel-7204).

Publisher

SAGE Publications

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Link

http://journals.sagepub.com/doi/pdf/10.1106/M4LK-LWJQ-34CL-LR85

Reference18 articles.

1. Polymer-controlled drug delivery systems

2. Pharmacokinetic evaluation of polymeric carriers

3. Soluble macromolecular carriers for the delivery of antitumour drugs

4. Manganese-DPDP as a Hepatobiliary Contrast Agent in the Magnetic Resonance Imaging of Liver Tumors: Results of Clinical Phase II Trials in Germany Including 141 Patients

Cited by 24 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Targeted Chemotherapy Based on Amplifying the Reactive Oxygen Species of Doxorubicin-Loaded Polyaspartamide-Encapsulated Iron Oxide Nanoparticles;ACS Applied Nano Materials;2022-05-12

2. Chemistry and Anticancer Activity of Hybrid Molecules and Derivatives based on 5-Fluorouracil;Current Medicinal Chemistry;2021-09-08

3. Tuning polymers grafted on upconversion nanoparticles for the delivery of 5-fluorouracil;European Polymer Journal;2020-08

4. Integration of iron oxide nanoparticles and polyaspartamide biopolymer for MRI image contrast enhancement and an efficient drug-delivery system in cancer therapy;Nanotechnology;2020-06-03

5. Encapsulation of superparamagnetic iron oxide nanoparticles with polyaspartamide biopolymer for hyperthermia therapy;European Polymer Journal;2020-01