Affiliation:
1. The Moscow Research and Clinical Center for Tuberculosis Control of the Moscow Government Department of Health;
Federal State Budgetary Educational Institution of Additional Professional Education “Russian Medical Academy of Continuing Professional Education” of the Ministry of Health of the Russian Federation, Department of Phthisiology
2. The Moscow Research and Clinical Center for Tuberculosis Control of the Moscow Government Department of Health
Abstract
The literature review is devoted to the characteristics of methods for diagnosing latent tuberculosis infection (LTBI) in various epidemiological and clinical situations. For many years, the tuberculin skin test (TST) has been used for these purposes. In the last decade, tests for assessing the production of interferon-γ (IFN-γ) with M. tuberculosis-specific antigens (ESAT6-CFP10) have become widespread. Recommendations for using these tests (and their combinations) are described. Currently, new skin tests (using the same antigens) have also been developed, which are used in practice (mainly in Russia). New in vitro tests have also been developed to determine other (except IFN-γ) interleukins, surface markers of T-lymphocytes, and microRNAs. Detection of an immune response against latent stage-specific M. tuberculosis (dormant) antigens should be optimal. Corresponding tests have been developed but have not yet found wide practical application.
Reference53 articles.
1. Aksenova V.A., Baryshnikova L.A., Dovgalyuk I.F., Dolzhenko E.N., Klevno N.I., Korneva N.V. i dr. Latentnaya tuberkuleznaya infektsiya (LTI) u detei. Klinicheskie rekomendatsii / Rossiiskoe obshchestvo ftiziatrov. – M., 2016. – 49 s.
2. Bogorodskaya E.M. Dlya chego nam neobkhodimo obsledovat' vzroslykh na latentnuyu tuberkuleznuyu infektsiyu? // Tuberkulez i sotsial'no znachimye zabolevaniya. – 2017. – № 2. – S. 3-5.
3. Bogorodskaya E.M., Slogotskaya L.V., Shamuratova L.F., Sevost'yanova T.A. Ckrining tuberkuleznoi infektsii u detei i podrostkov na osnove primeneniya 2-kh vnutrikozhnykh testov (s tuberkulinom i allergenom tuberkuleznym rekombinantnym (ESAT-6/CFP-10) v Moskve v 2021 godu // Tuberkulez i bolezni legkikh. – 2022. – T. 100. – № 11. – S. 29-38.
4. Kiselev V.I., Baranovskii P.M., Pupyshev S.A. i dr. Novyi kozhnyi test dlya diagnostiki tuberkuleza na osnove rekombinantnogo belka ESAT-CFP // Molekulyarnaya meditsina. – 2008. – № 4. – S. 4-6.
5. Kudlai D.A. Biomarkery i immunologicheskie testy. Eksperimental'no-klinicheskie paralleli latentnoi tuberkuleznoi infektsii // Tuberkulez i bolezni legkikh. – 2020. – T. 98. – № 8. – S. 63-74.