Effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 mid-season results-Reference-Cited by-同舟云学术

Effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 mid-season results

Published:2016-03-31 Issue:13 Volume:21 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Pebody Richard¹,Warburton Fiona¹,Ellis Joanna¹,Andrews Nick¹,Potts Alison²,Cottrell Simon³,Johnston Jillian⁴,Reynolds Arlene²,Gunson Rory⁵,Thompson Catherine¹,Galiano Monica¹,Robertson Chris⁶,Mullett David⁷,Gallagher Naomh⁴,Sinnathamby Mary¹,Yonova Ivelina⁷⁸,Moore Catherine³,McMenamin Jim²,de Lusignan Simon⁷⁸,Zambon Maria¹

Affiliation:

1. Public Health England, London, United Kingdom

2. Health Protection Scotland, Glasgow, United Kingdom

3. Public Health Wales, Cardiff, United Kingdom

4. Public Health Agency Northern Ireland, Belfast, United Kingdom

5. West of Scotland Specialist Virology Centre, Glasgow, United Kingdom

6. University of Strathclyde, Glasgow, United Kingdom

7. University of Surrey, Guildford, United Kingdom

8. Royal College of General Practitioners, Research and Surveillance Centre, London, United Kingdom

Abstract

In 2015/16, the influenza season in the United Kingdom was dominated by influenza A(H1N1)pdm09 circulation. Virus characterisation indicated the emergence of genetic clusters, with the majority antigenically similar to the current influenza A(H1N1)pdm09 vaccine strain. Mid-season vaccine effectiveness (VE) estimates show an adjusted VE of 41.5% (95% confidence interval (CI): 3.0–64.7) against influenza-confirmed primary care consultations and of 49.1% (95% CI: 9.3–71.5) against influenza A(H1N1)pdm09. These estimates show levels of protection similar to the 2010/11 season, when this strain was first used in the seasonal vaccine.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference15 articles.

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3. Evaluation of four real-time PCR assays for detection of influenza A(H1N1)v viruses.;Ellis;Euro Surveill,2009

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