2015/16 seasonal vaccine effectiveness against hospitalisation with influenza A(H1N1)pdm09 and B among elderly people in Europe: results from the I-MOVE+ project

Author:

Rondy Marc1,Larrauri Amparo23,Casado Itziar34,Alfonsi Valeria5,Pitigoi Daniela6,Launay Odile78,Syrjänen Ritva K9,Gefenaite Giedre10,Machado Ausenda11,Vučina Vesna Višekruna12,Horváth Judith Krisztina13,Paradowska-Stankiewicz Iwona14,Marbus Sierk D15,Gherasim Alin23,Díaz-González Jorge Alberto4,Rizzo Caterina5,Ivanciuc Alina E16,Galtier Florence717,Ikonen Niina18,Mickiene Aukse10,Gomez Veronica11,Kurečić Filipović Sanja12,Ferenczi Annamária13,Korcinska Monika R14,van Gageldonk-Lafeber Rianne15,Valenciano Marta1,

Affiliation:

1. EpiConcept, Paris, France

2. National Centre of Epidemiology, Institute of Health Carlos III, Madrid, Spain

3. CIBER Epidemiología y Salud Pública, Institute of Health Carlos III, Madrid, Spain

4. Instituto de Salud Pública de Navarra, IdiSNA, Pamplona, Spain

5. Istituto Superiore di Sanità, Rome, Italy

6. UMF Carol Davila, INC Cantacuzino, Bucharest, Romania

7. Inserm, F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC), Paris, France

8. Université Paris Descartes, Sorbonne Paris Cité, APHP, CIC Cochin-Pasteur, Paris, France

9. Impact Assessment Unit, National Institute for Health and Welfare, Tampere, Finland

10. Department of Infectious diseases, Lithuanian University of Health Sciences, Kaunas, Lithuania

11. Epidemiology Research Unit, Epidemiology Department, National Health Institute Dr Ricardo Jorge, Lisbon, Portugal

12. Epidemiology Service, Croatian Institute of Public Health, Zagreb, Croatia

13. Office of the Chief Medical Officer, Budapest, Hungary

14. National institute of Public Health - National Institute of Hygiene, Department of Epidemiology, Warsaw, Poland

15. Centre for Epidemiology and surveillance of infectious diseases, Centre for infectious disease control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands

16. INC Cantacuzino, Bucharest, Romania

17. CIC de Montpellier, Hôpital Saint-Eloi, CHU de Montpellier, Montpellier, France

18. Viral Infections Unit, National Institute for Health and Welfare, Helsinki, Finland

Abstract

We conducted a multicentre test-negative case–control study in 27 hospitals of 11 European countries to measure 2015/16 influenza vaccine effectiveness (IVE) against hospitalised influenza A(H1N1)pdm09 and B among people aged ≥ 65 years. Patients swabbed within 7 days after onset of symptoms compatible with severe acute respiratory infection were included. Information on demographics, vaccination and underlying conditions was collected. Using logistic regression, we measured IVE adjusted for potential confounders. We included 355 influenza A(H1N1)pdm09 cases, 110 influenza B cases, and 1,274 controls. Adjusted IVE against influenza A(H1N1)pdm09 was 42% (95% confidence interval (CI): 22 to 57). It was 59% (95% CI: 23 to 78), 48% (95% CI: 5 to 71), 43% (95% CI: 8 to 65) and 39% (95% CI: 7 to 60) in patients with diabetes mellitus, cancer, lung and heart disease, respectively. Adjusted IVE against influenza B was 52% (95% CI: 24 to 70). It was 62% (95% CI: 5 to 85), 60% (95% CI: 18 to 80) and 36% (95% CI: -23 to 67) in patients with diabetes mellitus, lung and heart disease, respectively. 2015/16 IVE estimates against hospitalised influenza in elderly people was moderate against influenza A(H1N1)pdm09 and B, including among those with diabetes mellitus, cancer, lung or heart diseases.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

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