An outbreak caused by the SARS-CoV-2 Delta (B.1.617.2) variant in a care home after partial vaccination with a single dose of the COVID-19 vaccine Vaxzevria, London, England, April 2021

Author:

Williams Sarah V1ORCID,Vusirikala Amoolya1ORCID,Ladhani Shamez N1,Fernandez Ruiz De Olano Elena2,Iyanger Nalini2,Aiano Felicity1,Stoker Kelly1,Gopal Rao Guduru3,John Laurence3,Patel Bharat1,Andrews Nick1,Dabrera Gavin1,Ramsay Mary1,Brown Kevin E1,Lopez Bernal Jamie1,Saliba Vanessa1

Affiliation:

1. National Infection Service, Public Health England, London, United Kingdom

2. London Coronavirus Response Centre, Public Health England, London, United Kingdom

3. London North West University Healthcare NHS Trust, London, United Kingdom

Abstract

We investigated a COVID-19 outbreak of the SARS-CoV-2 Delta variant of concern in a London care home, where 8/21 residents and 14/21 staff had received a single dose of Vaxzevria (ChAdOx1-S; AstraZeneca) vaccine. We identified 24 SARS-CoV-2 infections (16 residents, 8 staff) among 40 individuals (19 residents, 21 staff); four (3 residents, 1 staff) were hospitalised, and none died. The attack rate after one vaccine dose was 35.7% (5/14) for staff and 81.3% (13/16) for residents.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference18 articles.

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2. National Health System Test and Trace. Care home COVID-19 testing guidance: for testing of staff and residents. London: United Kingdom Government; 2021. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/988099/Care_Home_Testing_Guidance_England_v12-03_rev4_DIGITAL.pdf

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