Investigation into cases of hepatitis of unknown aetiology among young children, Scotland, 1 January 2022 to 12 April 2022

Author:

Marsh Kimberly1,Tayler Rachel2,Pollock Louisa3,Roy Kirsty1,Lakha Fatim1,Ho Antonia4,Henderson David1,Divala Titus1,Currie Sandra1,Yirrell David1,Lockhart Michael1,Rossi Maria K.1,Phin Nick1

Affiliation:

1. Public Health Scotland, Glasgow, United Kingdom

2. Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Children, Glasgow, Glasgow, United Kingdom

3. Department of Paediatric Infectious Diseases and Immunology, Royal Hospital for Children, Glasgow, United Kingdom

4. Medical Research Council-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom

Abstract

On 31 March 2022, Public Health Scotland was alerted to five children aged 3–5 years admitted to hospital with severe hepatitis of unknown aetiology. Retrospective investigation identified eight additional cases aged 10 years and younger since 1 January 2022. Two pairs of cases have epidemiological links. Common viral hepatitis causes were excluded in those with available results. Five children were adenovirus PCR-positive. Other childhood viruses, including SARS-CoV-2, have been isolated. Investigations are ongoing, with new cases still presenting.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference11 articles.

1. Acute infectious hepatitis in hospitalised children: a British Paediatric Surveillance Unit study.;Braccio;Arch Dis Child,2017

2. Age- and sex-related reference ranges of alanine aminotransferase levels in children: European paediatric HCV network.;England;J Pediatr Gastroenterol Nutr,2009

3. Scottish Government. COVID-19 Scotland’s Strategic Framework Update 2022. Edinburgh: Scottish Government. [Accessed: 12 Apr 2022]. Available from: https://www.gov.scot/binaries/content/documents/govscot/publications/strategy-plan/2022/02/coronavirus-covid-19-scotlands-strategic-framework-update-february-2022/documents/covid-19-scotlands-strategic-framework-update-february-2022/covid-19-scotlands-strategic-framework-update-february-2022/govscot%3Adocument/covid-19-scotlands-strategic-framework-update-february-2022.pdf.

4. Public Health Scotland. COVID-19 statistical report 6 April 2022. Edinburgh: Public Health Scotland. [Accessed: 12 Apr 2022]. Available from: https://publichealthscotland.scot/publications/covid-19-statistical-report/covid-19-statistical-report-6-april-2022/.

5. Office for National Statistics. Coronavirus (COVID-19) Infection Survey: Scotland. London: Office for National Statistics. [Accessed: 12 Apr 2022]. Available from: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/datasets/covid19infectionsurveyscotland.

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