Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February-Reference-Cited by-同舟云学术

Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February

Published:2021-03-18 Issue:11 Volume:26 Page:
ISSN:1560-7917
Container-title:Eurosurveillance
language:en
Short-container-title:

Author:

Grint Daniel J¹^ORCID,Wing Kevin¹,Williamson Elizabeth¹,McDonald Helen I¹,Bhaskaran Krishnan¹,Evans David²,Evans Stephen JW¹,Walker Alex J²,Hickman George²,Nightingale Emily³,Schultze Anna¹,Rentsch Christopher T¹,Bates Chris⁴,Cockburn Jonathan⁴,Curtis Helen J²,Morton Caroline E²,Bacon Sebastian²,Davy Simon²,Wong Angel YS¹,Mehrkar Amir²,Tomlinson Laurie¹,Douglas Ian J¹,Mathur Rohini¹,Blomquist Paula⁵,MacKenna Brian²,Ingelsby Peter²,Croker Richard²,Parry John⁴,Hester Frank⁴,Harper Sam⁴,DeVito Nicholas J²,Hulme Will²,Tazare John¹,Goldacre Ben⁶²,Smeeth Liam⁶¹,Eggo Rosalind M⁶¹

Affiliation:

1. Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom

2. The DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom

3. Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom

4. The Phoenix Partnership (TPP), TPP House, Leeds, United Kingdom

5. COVID-19 Outbreak Surveillance Team, Public Health England, London, United Kingdom

6. These authors contributed equally

Abstract

The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% confidence interval: 1.34–2.09; p < 0.0001). Absolute risk of death by 28 days increased with age and comorbidities. This VOC has potential to spread faster with higher mortality than the pandemic to date.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference13 articles.

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