First cases of SARS-CoV-2 BA.2.86 in Denmark, 2023

Author:

Rasmussen Morten12ORCID,Møller Frederik Trier13ORCID,Gunalan Vithiagaran2ORCID,Baig Sharmin4ORCID,Bennedbæk Marc2ORCID,Christiansen Lasse Engbo5ORCID,Cohen Arieh Sierra6ORCID,Ellegaard Kirsten4ORCID,Fomsgaard Anders2ORCID,Franck Kristina Træholt7ORCID,Larsen Nicolai Balle6ORCID,Larsen Tine Graakjær3ORCID,Lassaunière Ria2ORCID,Polacek Charlotta2ORCID,Qvesel Amanda Gammelby7ORCID,Sieber Raphael Niklaus4ORCID,Rasmussen Lasse Dam7ORCID,Stegger Marc84ORCID,Spiess Katja2ORCID,Tang Man-Hung Eric4ORCID,Vestergaard Lasse Skafte3ORCID,Andersen Thomas Emil910ORCID,Hoegh Silje Vermedal10ORCID,Pedersen Rune Micha910ORCID,Skov Marianne Nielsine910ORCID,Steinke Kat10ORCID,Sydenham Thomas Vognbjerg910ORCID,Hoppe Morten11,Nielsen Lene11,Krause Tyra Grove12ORCID,Ullum Henrik13ORCID,Jokelainen Pikka14ORCID

Affiliation:

1. These authors contributed equally to this work and share first authorship.

2. Virus Research and Development Laboratory, Virus & Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark

3. Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark

4. Sequencing and Bioinformatics, Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark

5. Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark

6. TestCenter Denmark, Statens Serum Institut, Copenhagen, Denmark

7. Virus Surveillance and Research Laboratory, Virus & Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark

8. Antimicrobial Resistance and Infectious Diseases Laboratory, Harry Butler Institute, Murdoch University, Perth, Australia

9. Research Unit for Clinical Microbiology, University of Southern Denmark, Odense, Denmark

10. Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark

11. Department of Clinical Microbiology, Copenhagen University Hospital, Herlev and Gentofte, Denmark

12. Epidemiological Infectious Disease Preparedness, Statens Serum Institut, Copenhagen, Denmark

13. Statens Serum Institut, Copenhagen, Denmark

14. Infectious Disease Preparedness, Statens Serum Institut, Copenhagen, Denmark

Abstract

We describe 10 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant BA.2.86 detected in Denmark, including molecular characteristics and results from wastewater surveillance that indicate that the variant is circulating in the country at a low level. This new variant with many spike gene mutations was classified as a variant under monitoring by the World Health Organization on 17 August 2023. Further global monitoring of COVID-19, BA.2.86 and other SARS-CoV-2 variants is highly warranted.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference13 articles.

1. Electronic reporting of diagnostic laboratory test results from all healthcare sectors is a cornerstone of national preparedness and control of COVID-19 in Denmark.;Schønning;APMIS,2021

2. The Danish Health Authority. Covid-19 test, symptoms, and early treatment. Copenhagen: Danish Health Authority. [Accessed: 28 Aug 2023]. Available from: https://www.sst.dk/en/english/Corona-eng/Guidelines-vaccination-and-disease-prevention/Test-symptoms-and-early-treatment

3. Statens Serum Institut (SSI). Virus monitoring at work. Copenhagen: SSI. [Accessed: 28 Aug 2023]. Available from: https://tcdk.ssi.dk/english/virus-monitoring-in-denmark

4. A RT-qPCR system using a degenerate probe for specific identification and differentiation of SARS-CoV-2 Omicron (B.1.1.529) variants of concern.;Jessen;PLoS One,2022

5. A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research.;Rihn;PLoS Biol,2021

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