Reduced risk of hospitalisation among reported COVID-19 cases infected with the SARS-CoV-2 Omicron BA.1 variant compared with the Delta variant, Norway, December 2021 to January 2022

Author:

Veneti Lamprini1ORCID,Bøås Håkon2,Bråthen Kristoffersen Anja3,Stålcrantz Jeanette42,Bragstad Karoline5,Hungnes Olav5,Storm Margrethe Larsdatter6,Aasand Nina6,Rø Gunnar3,Starrfelt Jostein1,Seppälä Elina2,Kvåle Reidar78,Vold Line1,Nygård Karin1,Buanes Eirik Alnes98,Whittaker Robert2

Affiliation:

1. Department of Infection Control and Preparedness, Norwegian Institute of Public Health, Oslo, Norway

2. Department of Infection Control and Vaccines, Norwegian Institute of Public Health, Oslo, Norway

3. Department of Method Development and Analytics, Norwegian Institute of Public Health, Oslo, Norway

4. European Program for Intervention Epidemiology Training, European Centre for Disease Prevention and Control, Stockholm, Sweden

5. Department of Virology, Norwegian Institute of Public Health, Oslo, Norway

6. Department of Infectious Disease Registries, Norwegian Institute of Public Health, Oslo, Norway

7. Department of Clinical Medicine, University of Bergen, Bergen, Norway

8. Department of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway

9. Norwegian Intensive Care and Pandemic Registry, Haukeland University Hospital, Bergen, Norway

Abstract

We included 39,524 COVID-19 Omicron and 51,481 Delta cases reported in Norway from December 2021 to January 2022. We estimated a 73% reduced risk of hospitalisation (adjusted hazard ratio: 0.27; 95% confidence interval: 0.20–0.36) for Omicron compared with Delta. Compared with unvaccinated groups, Omicron cases who had completed primary two-dose vaccination 7–179 days before diagnosis had a lower reduced risk than Delta (66% vs 93%). People vaccinated with three doses had a similar risk reduction (86% vs 88%).

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference15 articles.

1. Outbreak caused by the SARS-CoV-2 Omicron variant in Norway, November to December 2021.;Brandal;Euro Surveill,2021

2. Norwegian Institute of Public Health (FHI). Ukerapport uke 2 (10.01 - 16.01.22): Ukerapporter om koronavirus og covid-19. [Weekly report week 2 (10–16 Jan 2022): Weekly reports about coronavirus and COVID-19]. Oslo: FHI; 2022. Norwegian. Available from: https://www.fhi.no/contentassets/8a971e7b0a3c4a06bdbf381ab52e6157/vedlegg/2022/ukerapport-uke-2-10.01---16.01.22.pdf

3. Norwegian Institute of Public Health (FHI). Ukerapport uke 52 (27.12.21 - 02.01.22): Ukerapporter om koronavirus og covid-19. [Weekly report week 52 (27 Dec 2021–2 Jan 2022): Weekly reports about coronavirus and COVID-19]. Oslo: FHI; 2022. Norwegian. Available from: https://www.fhi.no/contentassets/8a971e7b0a3c4a06bdbf381ab52e6157/vedlegg/2021/ukerapport-uke-52-27.12.21---02.01.22.pdf

4. Norwegian Institute of Public Health (FHI). Emergency preparedness register for COVID-19 (Beredt C19). Oslo: FHI; 2021. Available from: https://www.fhi.no/en/id/infectious-diseases/coronavirus/emergency-preparedness-register-for-covid-19

5. Statens Serum Institut (SSI). Status of the SARS-CoV-2 variant Omicron in Denmark. Copenhagen: SSI; 2022. Available from: https://files.ssi.dk/covid19/omikron/statusrapport/rapport-omikronvarianten-03012022-9gj3

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