Estimated incubation period for monkeypox cases confirmed in the Netherlands, May 2022

Author:

Miura Fuminari12ORCID,van Ewijk Catharina E32ORCID,Backer Jantien A2,Xiridou Maria2,Franz Eelco2,Op de Coul Eline2,Brandwagt Diederik2,van Cleef Brigitte2,van Rijckevorsel Gini42,Swaan Corien2,van den Hof Susan2,Wallinga Jacco52

Affiliation:

1. Center for Marine Environmental Studies (CMES), Ehime University, Ehime, Japan

2. Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands

3. European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden

4. Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands

5. Department of Biomedical Data Sciences, Leiden University Medical Center (LUMC), Leiden, the Netherlands

Abstract

In May 2022, monkeypox outbreaks have been reported in countries not endemic for monkeypox. We estimated the monkeypox incubation period, using reported exposure and symptom-onset times for 18 cases detected and confirmed in the Netherlands up to 31 May 2022. Mean incubation period was 9.0 days* (5th–95th percentiles: 4.2–17.3), underpinning the current recommendation to monitor or isolate/quarantine case contacts for 21 days. However, as the incubation period may differ between different transmission routes, further epidemiological investigations are needed.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Subject

Virology,Public Health, Environmental and Occupational Health,Epidemiology

Reference13 articles.

1. World Health Organization (WHO). Multi-country monkeypox outbreak in non-endemic countries: Update. Geneva: WHO; 29 May 2022. [Accessed 3 Jun 2022]. Available from: https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON388

2. European Centre for Disease Prevention and Control (ECDC). Risk assessment: Monkeypox multi-country outbreak – 23 May 2022. Stockholm: ECDC; 2022. [Accessed 3 Jun 2022]. Available from: https://www.ecdc.europa.eu/en/publications-data/risk-assessment-monkeypox-multi-country-outbreak

3. United States Centers for Disease Control and Prevention (USCDC). Signs and Symptoms of monkeypox. Atlanta: USCDC; 2022 [Accessed 4 Jun 2022]. Available from: https://www.cdc.gov/poxvirus/monkeypox/symptoms.html

4. Clinical manifestations of human monkeypox influenced by route of infection.;Reynolds;J Infect Dis,2006

5. The changing epidemiology of human monkeypox-A potential threat? A systematic review.;Bunge;PLoS Negl Trop Dis,2022

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