FosA8-producing E. coli ST131: clinical cases in Italy, February 2023

Author:

Chudejova Katerina12,Caltagirone Maria Sofia3,Mattioni Marchetti Vittoria45ORCID,Rezzani Antonella3,Navarra Antonella3,Bitar Ibrahim12

Affiliation:

1. Biomedical Center, Faculty of Medicine, Charles University, Pilsen, Czechia

2. Department of Microbiology, Faculty of Medicine, University Hospital in Pilsen, Charles University, Pilsen, Czechia

3. Microbiology Unit, IRCCS Istituti Clinici Scientifici Maugeri, Pavia, Italy

4. Specialization School of Microbiology and Virology, University of Pavia, Pavia, Italy

5. Scienze Clinico, Chirurgiche, Diagnostiche, Pediatriche Department, Microbiology Unit, University of Pavia, Pavia, Italy

Abstract

Fosfomycin-resistant FosA8-producing Enterobacterales are uncommon strains with extremely low incidence in Europe, based on only three reports in the literature. We detected FosA8-producing Escherichia coli ST131 in clinical isolates from two patients admitted in February 2023 to a rehabilitation unit in Italy. The occurrence of rare fosA-like genes in the high-risk clone ST131 is of clinical relevance. The dissemination of FosA-producing E. coli, although still at low levels, should be continuously monitored.

Publisher

European Centre for Disease Control and Prevention (ECDC)

Reference13 articles.

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3. European Committee on Antimicrobial Susceptibility Testing (EUCAST). The 13.0 versions of breakpoints, dosing and QC (2023) published. Växjö: EUCAST; 2023. Available from: https://www.eucast.org/eucast_news/news_singleview?tx_ttnews%5Btt_news%5D=518&cHash=2509b0db92646dffba041406dcc9f20c

4. Polyclonal spread of fosfomycin resistance among carbapenemase-producing members of the Enterobacterales in the Czech Republic.;Mattioni Marchetti;Microbiol Spectr,2023

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1. FosA3 emerging in clinical carbapenemase-producing C. freundii;Frontiers in Cellular and Infection Microbiology;2024-08-06

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