Evaluation of 4 and 8 Weeks of Healing in a Murine Implant Model

Author:

Chalmers Jaclyn C.1,Silva Davi Neto de Araújo1,Casarin Maísa2,Monajemzadeh Sepehr1,Pirih Flavia Q.1

Affiliation:

1. 1  School of Dentistry, Section of Periodontics, University of California, Los Angeles, Los Angeles, California, United States.

2. 2  School of Dentistry, Department of Periodontology, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.

Abstract

Dental implants are increasing in prevalence as desirable options for replacing missing teeth. Unfortunately, implants come with complications, and animal models are crucial to studying the pathophysiology of complications. Current murine model experiments can be lengthy, with 8 weeks of extraction socket healing before implant placement. Therefore, we aimed to investigate the efficacy of decreasing extraction healing time from 8 to 4 weeks in a dental implant mouse model. Thirty-one 3-week-old C57BL/6J male mice underwent maxillary first and second molar extractions followed by 8 (control) or 4 (test) weeks of extraction socket healing before implant placement. Mice were euthanized after 4 weeks of implant osseointegration. Samples were analyzed via microcomputerized tomography and histology. When mice received implants 4 weeks after extractions, there was no statistical difference in initial bone crest remodeling or surrounding bone volume compared to those after 8 weeks of healing. Histologically, the hard and soft tissues surrounding both groups of implants displayed similar alveolar bone levels, inflammatory infiltrate, osteoclast count, and collagen organization. A 4-week extraction healing period can be utilized without concern for osseointegration in a murine implant model and is a viable experimental alternative to the previous eight weeks of healing. While small animal implant models are less directly applicable to humans, advancements in experimental methods will ultimately benefit patients receiving dental implants through improved prevention and treatment of complications. Subsequent research could investigate occlusal effects or whether healing time affects prognosis after induction of peri-implantitis.

Publisher

American Academy of Implant Dentistry

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