Signal transduction by vascular endothelial growth factor receptors-Reference-Cited by-同舟云学术

Signal transduction by vascular endothelial growth factor receptors

Published:2011-06-28 Issue:2 Volume:437 Page:169-183
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Koch Sina¹,Tugues Sònia¹,Li Xiujuan¹,Gualandi Laura¹,Claesson-Welsh Lena¹

Affiliation:

1. Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Dag Hammarskjöldsv. 20, 751 85 Uppsala, Sweden

Abstract

VEGFs (vascular endothelial growth factors) control vascular development during embryogenesis and the function of blood vessels and lymphatic vessels in the adult. There are five related mammalian ligands, which act through three receptor tyrosine kinases. Signalling is modulated through neuropilins, which act as VEGF co-receptors. Heparan sulfate and integrins are also important modulators of VEGF signalling. Therapeutic agents that interfere with VEGF signalling have been developed with the aim of decreasing angiogenesis in diseases that involve tissue growth and inflammation, such as cancer. The present review will outline the current understanding and consequent biology of VEGF receptor signalling.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/437/2/169/668599/bj4370169.pdf

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