Clinical, diagnostic, genetic and management issues in dementia with Lewy bodies

Author:

Boeve Bradley F.1

Affiliation:

1. Division of Behavioral Neurology, Department of Neurology, Mayo Clinic, Rochester, MN 559505, U.S.A.

Abstract

DLB (dementia with Lewy bodies) is a syndrome associated with underlying LBD (Lewy body disease), with manifestations in the cognitive, neuropsychiatric, motor, sleep and autonomic domains. The variable symptomatology and complex array of neuronal involvement and neurotransmitter deficiencies make the diagnosis and management of patients with DLB challenging. The genetic underpinnings of DLB have only recently begun to unfold. In this review, the clinical features, diagnostic criteria, genetics and treatment issues relating to DLB will be discussed, in which a comprehensive approach to the diagnosis and management is emphasized.

Publisher

Portland Press Ltd.

Subject

General Medicine

Reference97 articles.

1. Diffuse intracytoplasmic ganglionic inclusions (Lewy type) associated with progressive dementia and quadriparesis in flexion;Okazaki;J. Neuropathol. Exp. Neurol.,1961

2. Dementia and neuropathology in Lewy body disease;Kosaka;Adv. Neurol.,1993

3. Diffuse Lewy body disease;Kosaka;Neuropathology,2000

4. Tau and synuclein and their role in neuropathology;Dickson;Brain Pathol.,1999

5. Dementia with Lewy bodies: neuropathology;Dickson;J. Geriatr. Psychiatry Neurol.,2002

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