1. 1Academic Department of Medicine, The Royal Free Hospital, Pond Street, London NW3 2QG, U.K.
2. 2Academic Department of Medicine, The Royal Free Hospital, Pond Street, London NW3 2QG, U.K.
3. 3Academic Department of Medicine, The Royal Free Hospital, Pond Street, London NW3 2QG, U.K.
4. 4Academic Department of Medicine, The Royal Free Hospital, Pond Street, London NW3 2QG, U.K.