Affiliation:
1. Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093-0640, U.S.A.
Abstract
Phosphorylation plays a central role in regulating the activation and signalling lifetime of protein kinases A, B (also known as Akt) and C. These kinases share three conserved phosphorylation motifs: the activation loop segment, the turn motif and the hydrophobic motif. This review focuses on how phosphorylation at each of these sites regulates the maturation, signalling and down-regulation of PKC as a paradigm for how these sites control the function of the ABC kinases.
Subject
Cell Biology,Molecular Biology,Biochemistry
Cited by
680 articles.
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