Sputum Transcriptomics Reveals FCN1+ Macrophage Activation in Mild Eosinophilic Asthma Compared to Non-Asthmatic Eosinophilic Bronchitis

Author:

Zhan Wenzhi1ORCID,Luo Wei1ORCID,Zhang Yulong2ORCID,Xiang Keheng1ORCID,Chen Xiaomei1ORCID,Shen Shuirong1ORCID,Huang Chuqing1ORCID,Xu Tingting1ORCID,Ding Wenbin1ORCID,Chen Yuehan1ORCID,Lin Mingtong1ORCID,Pan Xinghua234ORCID,Lai Kefang1ORCID

Affiliation:

1. Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

2. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Southern Medical University, Guangzhou, China.

3. Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.

4. Department of Hepatobiliary Surgery II, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Funder

Key-Area Research and Development Program of Guangdong Province

Natural Science Foundation of Guangdong Province

Guangzhou Municipal Science and Technology Project

Incubative Project for Innovation Team of Guangzhou Medical University

Clinical Research Foundation of Guangzhou Medical University

Open Fund Programs of Shenzhen Bar Laboratory

National Natural Science Foundation of China

Publisher

XMLink

Subject

Pulmonary and Respiratory Medicine,Immunology,Immunology and Allergy

Reference51 articles.

1. Global Initiative for Asthma. Global strategy for asthma management and prevention (2022 Update) [Internet]. Fontana (WI). Global Initiative for Asthma. 2023. cited 2022 Sep 22. Available from: www.ginasthma.org

2. Global, regional, and national prevalence of asthma in 2019: a systematic analysis and modelling study

3. Asthma

4. Eosinophils and eosinophilic immune dysfunction in health and disease

5. CHRONIC COUGH: EOSINOPHILIC BRONCHITIS WITHOUT ASTHMA

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