Personality, Social Factors, Brain Functioning, Familial Risk, and Trajectories of Alcohol Misuse in Adolescence-Reference-Cited by-同舟云学术

Personality, Social Factors, Brain Functioning, Familial Risk, and Trajectories of Alcohol Misuse in Adolescence

Published:2024-08-16 Issue:8 Volume:7 Page:e2425114
ISSN:2574-3805
Container-title:JAMA Network Open
language:en
Short-container-title:JAMA Netw Open

Author:

Tschorn Mira¹²,Daedelow Laura²³⁴,Szalek Laura¹,Banaschewski Tobias²⁵,Bokde Arun L. W.⁶,Desrivières Sylvane⁷,Flor Herta⁸⁹,Grigis Antoine¹⁰,Garavan Hugh¹¹¹²,Gowland Penny¹³,Martinot Jean-Luc¹⁴,Martinot Marie-Laure Paillère¹⁴¹⁵,Artiges Eric¹⁶,Nees Frauke⁵⁸¹⁷,Orfanos Dimitri Papadopoulos¹⁰,Poustka Luise¹⁸,Hohmann Sarah⁵,Buechl Christian¹⁹,Smolka Michael N.¹⁹,Vaidya Nilakshi²⁰,Walter Henrik³,Whelan Robert²¹,Schumann Gunter²⁰²²,Heinz Andreas²³,Rapp Michael A.¹², ,Robbin Trevor²³,Dalley Jeffrey²³,Subramaniam Naresh²³,Theobald David²³,Mann Karl²³,Bach Christiane²³,Struve Maren²³,Rietschel Marcella²³,Spanagel Rainer²³,Fauth-Bühler Mira²³,Millenet Sabina²³,Grimmer Yvonne²³,Lathrop Mark²³,Albrecht Lisa²³,Ivanov Nikolay²³,Strache Nicole²³,Ströhle Andreas²³,Reuter Jan²³,Gallinat Jürgen²³,Gemmeke Isabel²³,Genauck Alexander²³,Parchetka Caroline²³,Weiß Katharina²³,Kruschwitz Johann²³,Raffaelli Bianca²³,Barbot Alexis²³,Thyreau Benjamin²³,Schwartz Yannick²³,Lalanne Christophe²³,Frouin Vincent Frouin25,²³,Rogers John²³,Ireland James²³,Lanzerath Dirk²³,Feng Jianfeng²³,Bricaud Zuleima²³,Gollier Briand Fanny²³,LemaÎtre Hervé²³,Miranda Ruben²³,Massicotte Jessica²³,Vulser Helene²³,Pentillä Jani²³,Filippi Irina²³,Galinowski André²³,Bezivin Pauline²³,Cattrell Anna²³,Jia Tianye²³,Werts Helen²³,Topper Lauren²³,Reed Laurence²³,Andrew Chris²³,Mallik Catherine²³,Ruggeri Barbara²³,Barker Gareth²³,Nymberg Charlotte²³,Conrod Patricia J.²³,Smith Lindsay²³,Loth Eva²³,Havatzias Stephanie²³,Kitson Emily²³,Robinson Alice²³,Hall Deborah²³,Rubino Chiara²³,Wright Hannah²³,Stueber Kerstin²³,Hanratty Eanna²³,Kennedy Eleanor²³,de Carvahlo Fabiana Mesquita²³,Stringaris Argyris²³,Ing Alex²³,Robert Gabriel²³,Macare Christine²³,Xu Bing²³,Yu Tao²³,Burke Quinlan Erin²³,Constant Patrick²³,Aydin Semiha²³,Brühl Ruediger²³,Ihlenfeld Albrecht²³,Walaszek Bernadeta²³,Ittermann Bernd²³,Smolka Michael²³,Hübner Thomas²³,Müller Kathrin²³,Ripke Stephan²³,Jurk Sarah²³,Mennigen Eva²³,Schmidt Dirk²³,Vetter Nora²³,Ziesch Veronika²³,Fröhner Juliane H.²³,Carter Daniel²³,O’Driscoll Susanne²³,Walsh Emily²³,Agan Maria Leonora Fatimah²³,McMorrow Mairead²³,Nugent Sinead²³,Connolly Colm²³,Dooley Eoin²³,Cremen Clodagh²³,Jones Jennifer²³,O’Keefe John²³,O’Connor Martin²³,Poline Jean-Baptiste²³,Bromberg Uli²³,Fadai Tahmine²³,Yacubian Juliana²³,Schneider Sophia²³,Lobatcheva Maria²³,Lawrence Claire²³,Newman Craig²³,Head Kay²³,Stedman Alicia²³,Heym Nadja²³,Kaviani Mehri²³,Paus Tomáš²³,Stephens Dai²³,Pausova Zdenka²³,Tahmasebi Amir²³

Affiliation:

1. Division of Social and Preventive Medicine, Department of Sports and Health Sciences, Intrafaculty unit of Cognitive Sciences, Faculty of Human Science, and Faculty of Health Sciences Brandenburg, Research Area Services Research and e-Health, University of Potsdam, Potsdam, Germany

2. German Center for Mental Health (DZPG), Berlin and Potsdam, Germany

3. Department of Psychiatry and Psychotherapy Campus Charité Mitte, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany

4. Department of Psychology, Humboldt-University Berlin, Germany

5. Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

6. Discipline of Psychiatry, School of Medicine, Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland

7. Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic, and Developmental Psychiatry Centre, King’s College London, London, United Kingdom

8. Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

9. Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany

10. NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France

11. Department of Psychiatry, University of Vermont, Burlington

12. Department of Psychology, University of Vermont, Burlington

13. Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom

14. Institut National de la Santé et de la Recherche Médicale, INSERM U 1299 Trajectoires Développementales & Psychiatrie, Ecole Normale Supérieure Paris-Saclay, Centre Borelli, University Paris Saclay, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France

15. Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Assistance Publique–Hôpitaux de Paris Sorbonne University, Paris, France

16. Institut National de la Santé et de la Recherche Médicale, Ecole Normale Supérieure Paris-Saclay, University Paris Saclay, Centre Borelli, CNRS, and Psychiatry Department, Établissement Public de Santé Barthélémy Durand, Etampes, France

17. Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany

18. Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, Germany

19. Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany

20. Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Germany

21. School of Psychology, Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland

22. Centre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-Inspired Intelligence (ISTBI), Fudan University, Shanghai, China

23. for the IMAGEN Consortium

Abstract

ImportanceThe development of an alcohol use disorder in adolescence is associated with increased risk of future alcohol dependence. The differential associations of risk factors with alcohol use over the course of 8 years are important for preventive measures.ObjectiveTo determine the differential associations of risk-taking aspects of personality, social factors, brain functioning, and familial risk with hazardous alcohol use in adolescents over the course of 8 years.Design, Setting, and ParticipantsThe IMAGEN multicenter longitudinal cohort study included adolescents recruited from European schools in Germany, the UK, France, and Ireland from January 2008 to January 2019. Eligible participants included those with available neuropsychological, self-report, imaging, and genetic data at baseline. Adolescents who were ineligible for magnetic resonance imaging or had serious medical conditions were excluded. Data analysis was conducted from July 2021 to September 2022.ExposurePersonality testing, psychosocial factors, brain functioning, and familial risk of alcohol misuse.Main Outcome and MeasuresHazardous alcohol use as measured with the Alcohol Use Disorders Identification Test scores, a main planned outcome of the IMAGEN study. Alcohol misuse trajectories at ages 14, 16, 19, and 22 years were modeled using latent growth curve models.ResultsA total of 2240 adolescents (1110 female [49.6%] and 1130 male [50.4%]) were included in the study. There was a significant negative association of psychosocial resources (β = −0.29; SE = 0.03; P &lt; .001) with the general risk of alcohol misuse as well as a significant positive association of the risk-taking aspects of personality with the intercept (β = 0.19; SE = 0.04; P &lt; .001). Furthermore, there were significant positive associations of the social domain (β = 0.13; SE = 0.02; P &lt; .001) and the personality domain (β = 0.07; SE = 0.02; P &lt; .001) with trajectories of alcohol misuse development over time (slope). Family history of substance misuse was negatively associated with general risk of alcohol misuse (β = −0.04; SE = 0.02; P = .045) and its development over time (β = −0.03; SE = 0.01; P = .01). Brain functioning showed no significant association with intercept or slope of alcohol misuse in the model.Conclusions and RelevanceThe findings of this cohort study suggest known risk factors of adolescent drinking may contribute differentially to future alcohol misuse. This approach may inform more individualized preventive interventions.

Publisher

American Medical Association (AMA)

Link

https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2822424/tschorn_2024_oi_240788_1723143831.28871.pdf

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