Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative

Author:

Bennett Tellen D.1,Moffitt Richard A.2,Hajagos Janos G.3,Amor Benjamin4,Anand Adit3,Bissell Mark M.4,Bradwell Katie Rebecca4,Bremer Carolyn3,Byrd James Brian5,Denham Alina6,DeWitt Peter E.1,Gabriel Davera7,Garibaldi Brian T.8,Girvin Andrew T.4,Guinney Justin9,Hill Elaine L.6,Hong Stephanie S.8,Jimenez Hunter3,Kavuluru Ramakanth10,Kostka Kristin1112,Lehmann Harold P.13,Levitt Eli14,Mallipattu Sandeep K.3,Manna Amin4,McMurry Julie A.15,Morris Michele16,Muschelli John17,Neumann Andrew J.15,Palchuk Matvey B.18,Pfaff Emily R.19,Qian Zhenglong2,Qureshi Nabeel4,Russell Seth1,Spratt Heidi20,Walden Anita921,Williams Andrew E.22,Wooldridge Jacob T.3,Yoo Yun Jae3,Zhang Xiaohan Tanner8,Zhu Richard L.8,Austin Christopher P.23,Saltz Joel H.2,Gersing Ken R.23,Haendel Melissa A.1824,Chute Christopher G.25826,Gagnier Joel27,Hu Siqing27,Lota Kanchan27,Maidlow Sarah27,Hanauer David A.27,Weatherwax Kevin27,Gandrakota Nikhila27,Kamaleswaran Rishikesan27,Martin Greg27,Qian Jingjing27,Farley Jason E.27,Francis Patricia A.27,Jiao Dazhi27,Kharrazi Hadi27,Reese Justin T.27,Deacy Mariam27,Sheikh Usman27,Chen Jake27,Patton Michael27,Ramsey Thomas27,Singh Jasvinder27,Cimino James J.27,Su Jing27,Adams William G27,Duong Tim27,Buse John B.27,Islam Jessica Yasmine27,Obeid Jihad S.27,Meystre Stephane27,Patterson Steve27,Zemmel Misha27,Grider Ron27,Martinez Ashley27,Santos Carlos27,Solway Julian27,Chiu Ryan27,Brown Gerald B.27,Cui Jiafeng27,Liang Sharon27,Khanipov Kamil27,Harper Jeremy Richard27,Embi Peter J.27,Eichmann David A.27,Knosp Boyd M.27,Hillegass William27,Wu Chunlei27,Aaron James27,Henderson Darren27,Gul Muhammad27,Harper Tamela27,Harris Daniel27,Talbert Jeff27,Bahroos Neil27,Dubinett Steven27,Mathew Jomol27,McMahan Gabriel27,Liu Hongfang27,Lucchinetti Claudia27,Schwartz David L27,Sacco Ralph27,Taghioff Peyman27,Harper Diane27,Angst Denise27,Marek Andrew27,Figueroa Castro Carlos E.27,Blazar Bruce27,Johnson Steven G.27,Basford Melissa27,Jones Laura27,Bernard Gordon27,Wright Rosalind27,Finkelstein Joseph27,Campion Thomas R.27,Mason Christopher E.27,Fuld Xiaobo27,Anzalone Alfred27,McClay James C.27,Visweswaran Shyam27,Cook Connor27,Dest Alexandra27,Ellison David27,Relevo Rose27,Volz Andrea M.27,Zhang Chengda27,Tenzer Martha27,Bowers David S.27,Farrell Francis27,Qin Qiuyuan27,Zand Martin27,Holden-Wiltse Jeanne27,Gouripeddi Ramkiran27,Facelli Julio27,Clark Robert27,Becerra Benjamin27,Yan Yao27,Phuong Jimmy27,Chae Yooree27,Patel Rena C.27,Suver Christine27,Zampino Elizabeth27,Said Ahmed S.27,Payne Philip R.O.27,Jawa Randeep27,Elkin Peter L.27,Koraishy Farrukh M27,Golovko George27,Subbian Vignesh27,Weisdorf Daniel27,Sinoway Lawrence27,Morizono Hiroki27,Crandall Keith A.27,Rahnavard Ali27,Shara Nawar27,Taxter Alysha27,Ostasiewski Brian27,Song Qianqian27,Vangala Uma Maheswara Reddy27,De Luzuriaga Katherine Ruiz27,Khatib Rasha27,Kirwan John27,von Oehsen James27,Moore Jason27,Sakhuja Ankit27,Rutter Joni27,

Affiliation:

1. Section of Informatics and Data Science, Department of Pediatrics, University of Colorado School of Medicine, University of Colorado, Aurora

2. Department of Biomedical Informatics, Stony Brook University, Stony Brook, New York

3. Stony Brook University, Stony Brook, New York

4. Palantir Technologies, Denver, Colorado

5. Department of Internal Medicine, The University of Michigan at Ann Arbor, Ann Arbor

6. Department of Public Health Sciences, University of Rochester Medical Center, Rochester, New York

7. Institute for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, Maryland

8. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland

9. Sage Bionetworks, Seattle, Washington

10. Division of Biomedical Informatics, Department of Internal Medicine, University of Kentucky, Lexington

11. Real World Solutions, IQVIA, Cambridge, Massachusetts

12. Observational Health Data Sciences and Informatics, New York, New York

13. Division of Health Science Informatics, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland

14. Department of Orthopaedic Surgery, University of Alabama at Birmingham, Birmingham

15. Translational and Integrative Sciences Center, Oregon State University, Corvallis

16. Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania

17. Department of Biostatistics, Johns Hopkins University School of Medicine, Baltimore, Maryland

18. TriNetX, Cambridge, Massachusetts

19. North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill, Chapel Hill

20. Department of Preventive Medicine and Public Health, University of Texas Medical Branch, Galveston

21. Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland

22. Tufts Medical Center Clinical and Translational Science Institute, Tufts Medical Center, Boston, Massachusetts

23. National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland

24. Center for Health AI, University of Colorado, Aurora

25. Department of Health Policy and Management, Johns Hopkins University School of Medicine, Baltimore, Maryland

26. Department of Nursing, Johns Hopkins University School of Medicine, Baltimore, Maryland

27. for the National COVID Cohort Collaborative (N3C) Consortium

Publisher

American Medical Association (AMA)

Subject

General Medicine

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