Shared Risk Factors for Depressive Disorder Among Older Adult Couples in Korea-Reference-Cited by-同舟云学术

Shared Risk Factors for Depressive Disorder Among Older Adult Couples in Korea

Published:2023-04-14 Issue:4 Volume:6 Page:e238263
ISSN:2574-3805
Container-title:JAMA Network Open
language:en
Short-container-title:JAMA Netw Open

Author:

Han Ji Won¹²,Yang Hee Won³,Bae Jong Bin¹²,Oh Dae Jong⁴,Moon Dong Gyu¹,Lim Eunji⁵,Shin Jin¹,Kim Bong Jo⁶,Lee Dong Woo⁷,Kim Jeong Lan⁸,Jhoo Jin Hyeong⁹,Park Joon Hyuk¹⁰,Lee Jung Jae¹¹,Kwak Kyung Phil¹²,Lee Seok Bum¹¹,Moon Seok Woo¹³,Ryu Seung-Ho¹⁴,Kim Shin Gyeom¹⁵,Kim Ki Woong¹²¹⁶

Affiliation:

1. Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea

2. Department of Psychiatry, Seoul National University, College of Medicine, Seoul, South Korea

3. Department of Psychiatry, Chungnam National University Hospital, Daejeon, South Korea

4. Workplace Mental Health Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea

5. Department of Neuropsychiatry, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea

6. Department of Psychiatry, Gyeongsang National University, School of Medicine, Jinju, South Korea

7. Department of Neuropsychiatry, Inje University Sanggye Paik Hospital, Seoul, South Korea

8. Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, South Korea

9. Department of Neuropsychiatry, Kangwon National University Hospital, Chuncheon, South Korea

10. Department of Neuropsychiatry, Jeju National University Hospital, Jeju, South Korea

11. Department of Psychiatry, Dankook University Hospital, Cheonan, South Korea

12. Department of Psychiatry, Dongguk University Gyeongju Hospital, Gyeongju, South Korea

13. Department of Psychiatry, School of Medicine, Konkuk University and Konkuk University Chungju Hospital, Chungju, South Korea

14. Department of Psychiatry, School of Medicine, Konkuk University and Konkuk University Medical Center, Seoul, South Korea

15. Department of Neuropsychiatry, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea

16. Department of Brain and Cognitive Science, Seoul National University College of Natural Sciences, Seoul, South Korea

Abstract

ImportanceAlthough couples may share many risk factors for depressive disorders in their lifetime, whether these factors mediate the shared risk of depressive disorders has rarely been investigated.ObjectivesTo identify the shared risk factors for depressive disorder in couples and investigate their mediating roles in the shared risk of depressive disorders among older adult couples.Design, Setting, and ParticipantsThis nationwide, multicenter, community-based cohort study assessed 956 older adults from the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD) and a cohort of their spouses (KLOSCAD-S) between January 1, 2019, to February 28, 2021.ExposuresDepressive disorders of the KLOSCAD participants.Main Outcomes and MeasuresThe mediating roles of shared factors in couples on the association between one spouse’s depressive disorder and the other’s risk of depressive disorders was examined using structural equation modeling.ResultsA total of 956 KLOSCAD participants (385 women [40.3%] and 571 men [59.7%]; mean [SD] age, 75.1 [5.0] years) and their spouses (571 women [59.7%] and 385 men [40.3%]; mean [SD] age, 73.9 [6.1] years) were included. The depressive disorders of the KLOSCAD participants were associated with an almost 4-fold higher risk of depressive disorders in their spouses in the KLOSCAD-S cohort (odds ratio, 3.89; 95% CI, 2.06-7.19; P &lt; .001). Social-emotional support mediated the association between depressive disorders in the KLOSCAD participants and their spouses’ risk of depressive disorders by itself (β = 0.012; 95% CI, 0.001-0.024; P = .04; mediation proportion [MP] = 6.1%) and through chronic illness burden (β = 0.003; 95% CI, 0.000-0.006; P = .04; MP = 1.5%). Chronic medical illness burden (β = 0.025; 95% CI, 0.001-0.050; P = .04; MP = 12.6%) and presence of a cognitive disorder (β = 0.027; 95% CI, 0.003-0.051; P = .03; MP = 13.6%) mediated the association.Conclusions and RelevanceThe risk factors shared by older adult couples may mediate approximately one-third of the spousal risk of depressive disorders. Identification of and intervention in the shared risk factors of depression among older adult couples may reduce the risk of depressive disorders in the spouses of older adults with depression.

Publisher

American Medical Association (AMA)

Subject

General Medicine

Link

https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2803895/han_2023_oi_230263_1680884414.84762.pdf

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