Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism

Author:

Mooijaart Simon P.12,Du Puy Robert S.3,Stott David J.4,Kearney Patricia M.5,Rodondi Nicolas67,Westendorp Rudi G. J.89,den Elzen Wendy P. J.10,Postmus Iris12,Poortvliet Rosalinde K. E.3,van Heemst Diana1,van Munster Barbara C.11,Peeters Robin P.12,Ford Ian13,Kean Sharon13,Messow Claudia-Martina13,Blum Manuel R.614,Collet Tinh-Hai15,Watt Torquil16,Dekkers Olaf M.17,Jukema J. Wouter18,Smit Johannes W. A.19,Langhorne Peter20,Gussekloo Jacobijn13

Affiliation:

1. Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands

2. Institute for Evidence-Based Medicine in Old Age, Leiden, the Netherlands

3. Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands

4. Geriatric Medicine, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom

5. School of Public Health, University College Cork, Cork, Ireland

6. Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

7. Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland

8. Department of Public Health, University of Copenhagen, Copenhagen, Denmark

9. Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark

10. Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, the Netherlands

11. Department of Internal Medicine, Academic Medical Center, Amsterdam, the Netherlands

12. Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, the Netherlands

13. Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom

14. Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California

15. Service of Endocrinology, Diabetes and Metabolism, Lausanne University Hospital, Lausanne, Switzerland

16. Department of Internal Medicine, Copenhagen University Hospital Herlev, Gentofte, Denmark

17. Department of Endocrinology and Metabolic Disorders, Leiden University Medical Center, Leiden, the Netherlands

18. Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands

19. Radboud University Medical Center, Nijmegen, the Netherlands

20. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom

Publisher

American Medical Association (AMA)

Subject

General Medicine

Reference32 articles.

1. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III).;Hollowell;J Clin Endocrinol Metab,2002

2. Endogenous subclinical hyperthyroidism affects quality of life and cardiac morphology and function in young and middle-aged patients.;Biondi;J Clin Endocrinol Metab,2000

3. The effects of early antithyroid therapy for endogenous subclinical hyperthyroidism in clinical and heart abnormalities.;Sgarbi;J Clin Endocrinol Metab,2003

4. Subclinical hypothyroidism and the risk of coronary heart disease: a meta-analysis.;Rodondi;Am J Med,2006

5. Thyroid hormone therapy for older adults with subclinical hypothyroidism.;Stott;N Engl J Med,2017

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