Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight

Author:

Tyrrell Jessica1,Richmond Rebecca C.2,Palmer Tom M.3,Feenstra Bjarke4,Rangarajan Janani5,Metrustry Sarah6,Cavadino Alana7,Paternoster Lavinia8,Armstrong Loren L.9,De Silva N. Maneka G.8,Wood Andrew R.10,Horikoshi Momoko11,Geller Frank4,Myhre Ronny12,Bradfield Jonathan P.13,Kreiner-Møller Eskil14,Huikari Ville15,Painter Jodie N.16,Hottenga Jouke-Jan17,Allard Catherine18,Berry Diane J.19,Bouchard Luigi20,Das Shikta21,Evans David M.22,Hakonarson Hakon23,Hayes M. Geoffrey9,Heikkinen Jani24,Hofman Albert25,Knight Bridget10,Lind Penelope A.16,McCarthy Mark I.26,McMahon George27,Medland Sarah E.16,Melbye Mads28,Morris Andrew P.29,Nodzenski Michael5,Reichetzeder Christoph30,Ring Susan M.31,Sebert Sylvain32,Sengpiel Verena33,Sørensen Thorkild I. A.34,Willemsen Gonneke17,de Geus Eco J. C.17,Martin Nicholas G.16,Spector Tim D.6,Power Christine19,Järvelin Marjo-Riitta32,Bisgaard Hans14,Grant Struan F. A.23,Nohr Ellen A.35,Jaddoe Vincent W.36,Jacobsson Bo37,Murray Jeffrey C.38,Hocher Berthold39,Hattersley Andrew T.10,Scholtens Denise M.5,Davey Smith George31,Hivert Marie-France40,Felix Janine F.36,Hyppönen Elina41,Lowe William L.9,Frayling Timothy M.10,Lawlor Debbie A.31,Freathy Rachel M.42,

Affiliation:

1. Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, United Kingdom2European Centre for Environment and Human Health, University of Exeter, the Knowledge Spa, Truro, United Kingdom

2. School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, United Kingdom4The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands5Medical Research Council Inte

3. Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, United Kingdom7Department of Mathematics and Statistics, Lancaster University, Lancaster, United Kingdom

4. Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark

5. Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois

6. Department of Twin Research, King's College London, St Thomas' Hospital, London, United Kingdom

7. Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts, and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom12Population, Policy and Practice, UCL Institute of Child He

8. Medical Research Council Integrative Epidemiology Unit at the University of Bristol, United Kingdom

9. Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois

10. Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, United Kingdom

11. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, United Kingdom15Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

12. Division of Epidemiology, Department of Genes and Environment, Norwegian Institute of Public Health, Oslo, Norway

13. Center for Applied Genomics, the Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania

14. Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, and Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark

15. Institute of Health Sciences, University of Oulu, Oulu, Finland

16. QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Herston, Australia

17. EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands22Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands

18. Department of Mathematics, Universite de Sherbrooke, Quebec City, Quebec, Canada24Centre de recherché du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec City, Quebec, Canada

19. Population, Policy and Practice, UCL Institute of Child Health, University College London, United Kingdom

20. Centre de recherché du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec City, Quebec, Canada25ECOGENE-21 and Lipid Clinic, Chicoutimi Hospital, Saguenay, Quebec City, Quebec, Canada26Department of Biochemistry, Université de Sherbrooke,

21. Department of Primary Care and Public Health, Imperial College London, United Kingdom

22. School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, United Kingdom5Medical Research Council Integrative Epidemiology Unit at the University of Bristol, United Kingdom28University of Queensland Diamantin

23. Center for Applied Genomics, the Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania29Division of Human Genetics, the Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania30Department of Pediatrics, Perelman School of Medicine, Unive

24. FIMM Institute for Molecular Medicine Finland, Helsinki University, Helsinki, Finland

25. Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands54Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts

26. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, United Kingdom15Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom33Oxford National Institute for Health Research (NIHR) Biomedical Researc

27. School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, United Kingdom

28. Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark34Department of Medicine, Stanford University School of Medicine, Stanford, California

29. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom35Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom

30. Institute of Nutritional Science, University of Potsdam, Germany37Center for Cardiovascular Research/Charité, Berlin, Germany

31. School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, United Kingdom5Medical Research Council Integrative Epidemiology Unit at the University of Bristol, United Kingdom

32. Institute of Health Sciences, University of Oulu, Oulu, Finland38Department of Epidemiology and Biostatistics, School of Public Health, Medical Research Council-Health Protection Agency Centre for Environment and Health, Faculty of Medicine, Imperial Coll

33. Department of Obstetrics and Gynecology, Sahlgrenska Academy, Sahgrenska University Hospital, Gothenburg, Sweden

34. Medical Research Council Integrative Epidemiology Unit at the University of Bristol, United Kingdom40Institute of Preventive Medicine, Bispebjerg and Frederiksberg University Hospital, Capital Region, Copenhagen, Denmark41Novo Nordisk Foundation Center fo

35. Research Unit of Obstetrics & Gynecology, Institute of Clinical Research, University of Southern Denmark, Odense

36. The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands32Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands46Department of Pediatrics, Erasmus MC, University Medic

37. Division of Epidemiology, Department of Genes and Environment, Norwegian Institute of Public Health, Oslo, Norway39Department of Obstetrics and Gynecology, Sahlgrenska Academy, Sahgrenska University Hospital, Gothenburg, Sweden

38. Department of Pediatrics, University of Iowa, Iowa City

39. Institute of Nutritional Science, University of Potsdam, Germany48The First Affiliated Hospital of Jinan University, Guangzhou, China

40. Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, Massachusetts50Diabetes Center, Massachusetts General Hospital, Boston51Department of Medicine, Universite de Sherbrooke, Quebec City, Quebec, Canada

41. Population, Policy and Practice, UCL Institute of Child Health, University College London, United Kingdom52Centre for Population Health Research, School of Health Sciences, and Sansom Institute, University of South Australia, Adelaide53South Australian He

42. Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, United Kingdom5Medical Research Council Integrative Epidemiology Unit at the University of Bristol, United Kingdom

Publisher

American Medical Association (AMA)

Subject

General Medicine

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