Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19
Author:
, Domingo Pere1, Mur Isabel1, Mateo Gracia María1, Gutierrez Maria del Mar1, Pomar Virginia1, de Benito Natividad1, Corbacho Noemí1, Herrera Silvia1, Millan Lucia1, Muñoz Jessica1, Malouf Jorge1, Molas Maria Ema1, Asensi Victor1, Horcajada Juan Pablo1, Estrada Vicente1, Gutierrez Felix1, Torres Ferran1, Perez-Molina Jose A1, Fortun Jesús1, Villar Luisa M1, Hohenthal Ulla1, Marttila Harri1, Vuorinen Tytti1, Nordberg Marika1, Valtonen Mika1, Frigault Matthew J1, Mansour Michael K1, Patel Naomi J1, Fernandes Ana1, Harvey Liam1, Foulkes Andrea S1, Healy Brian C1, Shah Ruta1, Bensaci Ana Maria1, Woolley Ann E.1, Nikiforow Sarah1, Lin Nina1, Sagar Manish1, Shrager Harry1, Huckins David S.1, Axelrod Matthew1, Pincus Michael D1, Fleisher Jorge1, Lampa Jon1, Nowak Piotr1, Vesterbacka Jan C.1, Rasmuson Johan1, Skorup Paul1, Janols Helena1, Niward Katarina F1, Chatzidionysiou Katerina1, Asgeirsson Hilmir1, Parke Åsa1, Blennow Ola1, Svensson Anna-Karin1, Aleman Soo 1, Sönnerborg Anders1, Henter Jan-Inge1, Horne Anna Carin1, Al-Beidh Farah1, Angus Derek1, Annane Djillali1, Arabi Yaseen1, Beane Abigail1, Berry Scott1, Bhimani Zahra1, Bonten Marc1, Bradbury Charlotte1, Brunkhorst Frank1, Buxton Meredith1, Cheng Allen1, Cove Matt1, De Jong Menno1, Derde Lennie1, Estcourt Lise1, Goossens Herman1, Gordon Anthony1, Green Cameron1, Haniffa Rashan1, Ichihara Nao1, Lamontagne Francois1, Lawler Patrick1, Litton Ed1, Marshall John1, McArthur Colin1, McAuley Daniel1, McGuinness Shay1, McVerry Bryan1, Montgommery Stephanie1, Mouncey Paul1, Murthy Srinivas1, Nichol Alistair1, Parke Rachael1, Parker Jane1, Reyes Felipe1, Rowan Kathryn1, Saito Hiroki1, Santos Marlene1, Seymour Chris1, Shankar-Hari Manu1, Turgeon Alexis1, Turner Anne1, van Bentum-Puijk Wilma1, van de Veerdonk Frank1, Webb Steve1, Zarychanski Ryan1, Baillie J Kenneth1, Beasley Richard1, Cooper Nichola1, Fowler Robert1, Galea James1, Hills Thomas1, King Andrew1, Morpeth Susan1, Netea Mihai1, Ogungbenro Kayode1, Pettila Ville1, Tong Steve1, Uyeki Tim1, Youngstein Taryn1, Higgins Alisa1, Lorenzi Elizabeth1, Berry Lindsay1, Salama Carlos1, Rosas Ivan O.1, Ruiz-Antorán Belén1, Muñez Rubio Elena1, Ramos Martínez Antonio1, Campos Esteban José1, Avendaño Solá Cristina1, Pizov Reuven1, Sanz Sanz Jesus1, Abad-Santos Francisco1, Bautista-Hernández Azucena1, García-Fraile Lucio1, Barrios Ana1, Gutiérrez Liarte Ángela1, Alonso Pérez Tamara1, Rodríguez-García Sebastian C1, Mejía-Abril Gina1, Prieto Jose Carlos1, Leon Rafael1, VEIGA VIVIANE C.1, SCHEINBERG PHILLIP1, FARIAS DANIELLE L.C.1, PRATS JOÃO G.1, CAVALCANTI ALEXANDRE B.1, MACHADO FLAVIA R.1, ROSA REGIS G.1, BERWANGER OTÁVIO1, AZEVEDO LUCIANO C.P.1, LOPES RENATO D.1, DOURADO LETICIA K.1, CASTRO CLAUDIO G.1, ZAMPIERI FERNANDO G.1, AVEZUM ALVARO1, LISBOA THIAGO C.1, ROJAS SALOMÓN S.O.1, COELHO JULIANA C.1, LEITE RODRIGO T.1, CARVALHO JULIO CESAR1, ANDRADE LUIS E.C.1, SANDES ALEX R.1, PINTÃO MARIA CAROLINA T.1, SANTOS SUELI V.1, ALMEIDA THIAGO M.L.1, COSTA ANDRÉ N.1, GEBARA OTAVIO C.E.1, FREITAS FLAVIO G.R.1, PACHECO EDUARDO S.1, MACHADO DAVID J.B.1, MARTIN JOSIANE1, CONCEIÇÃO FABIO G.1, SIQUEIRA SUELLEN R.R.1, DAMIANI LUCAS P.1, ISHIHARA LUCIANA M.1, SCHNEIDER DANIEL1, DE SOUZA DENISE1, Hermine Olivier1, Mariette Xavier1, Tharaux Pierre Louis1, Resche Rigon Matthieu1, Porcher Raphael1, Ravaud Philippe1, Azoulay Elie1, Cadranel Jacques1, Emmerich Joseph1, Fartoukh Muriel1, Guidet Bertrand1, Humbert Marc1, Lacombe Karine1, Mahevas Matthieu1, Pene Frédéric1, Pourchet-Martinez Valérie1, Schlemmer Frédéric1, Tibi Annick1, Yazdanpanah Yazdan1, Dougados Maxime1, Bureau Serge1, Horby Peter W1, Landray Martin J1, Baillie Kenneth J1, Buch Maya H1, Chappell Lucy C1, Day Jeremy N1, Faust Saul N1, Haynes Richard1, Jaki Thomas1, Jeffery Katie1, Juszczak Edmund1, Lim Wei Shen1, Mafham Marion1, Montgomery Alan1, Mumford Andrew1, Thwaites Guy1, Kamarulzaman Adeeba1, Syed Omar Sharifah Faridah1, Ponnampalavanar Sasheela1, Raja Azwa Raja Iskandar Syah1, Wong Pui Li1, Kukreja Anjanna1, Ong Hang Cheng1, Sulaiman Helmi1, Basri Sazali1, Ng Rong Xiang1, Megat Johari Bushra1, Rajasuriar Reena1, Chong Meng Li1, Neelamegam Malinee1, Syed Mansor Syed Mukhtar1, Zulhaimi Nurul Syuhada1, Lee Cheng Siang1, Altice Frederick1, Price Christina1, Malinis Maricar1, Hasan Mohd Shahnaz1, Wong Chee Kuan1, Chidambaram Suresh1, Misnan Nor Arisah1, Mohd Thabit Alif Adlan1, Sim Benedict1, Bidin Farah Nadiah1, Mohd Abd Rahim Mohd Abd Hafiz1, Saravanamuttu Sujana1, Tuang Wei Xuan1, Mohamed Gani Yasmin1, Thangavelu Suvintheran1, Tay Kim Heng1, Ibrahim Nur Munirah1, Halid Luqman Alhakim1, Tan Kok Tong1, Mukri Mohd Noor Azreet1, Arip Masita1, Koh Hui Moon1, Syed Badaruddin Syarifah Nurul Ain1, Raja Sureja Letchumi1, Chun Geok Ying1, TORRE-CISNEROS JULIAN1, MERCHANTE NICOLAS1, LEON RAFAEL1, CARCEL SHEILA1, GARRIDO JOSE CARLOS1, Galun Eitan1, Soriano Alex1, Martínez José Antonio1, Castán Clara1, Paredes Roger1, Dalmau David1, Carbonell Cristina1, Espinosa Gerard1, Castro Pedro1, Muñóz José1, Almuedo Alex1, Prieto Sergio1, Pacheco Iván1, Ratain Mark1, Pisano Jennifer1, Strek Mary1, Adegunsoye Ayodeji1, Karrison Theodore1, Jozefien Declercq1, Karel F.A. Van Damme1, Elisabeth De Leeuw1, Cedric Bosteels1, Bastiaan Maes1, Shankar-Hari Manu23, Vale Claire L.4, Godolphin Peter J.4, Fisher David4, Higgins Julian P. T.567, Spiga Francesca8, Savovic Jelena57, Tierney Jayne4, Baron Gabriel910, Benbenishty Julie S.11, Berry Lindsay R.12, Broman Niklas13, Cavalcanti Alexandre Biasi14, Colman Roos15, De Buyser Stefanie L.15, Derde Lennie P. G.16, Domingo Pere17, Omar Sharifah Faridah18, Fernandez-Cruz Ana19, Feuth Thijs20, Garcia Felipe21, Garcia-Vicuna Rosario22, Gonzalez-Alvaro Isidoro22, Gordon Anthony C.23, Haynes Richard2425, Hermine Olivier2627, Horby Peter W.282930, Horick Nora K.31, Kumar Kuldeep3233, Lambrecht Bart N.3435, Landray Martin J.2425, Leal Lorna21, Lederer David J.36, Lorenzi Elizabeth12, Mariette Xavier3738, Merchante Nicolas39, Misnan Nor Arisah40, Mohan Shalini V.41, Nivens Michael C.36, Oksi Jarmo13, Perez-Molina Jose A.42, Pizov Reuven43, Porcher Raphael91044, Postma Simone45, Rajasuriar Reena1846, Ramanan Athimalaipet V.47, Ravaud Philippe91044, Reid Pankti D.48, Rutgers Abraham45, Sancho-Lopez Aranzazu49, Seto Todd B.50, Sivapalasingam Sumathi36, Soin Arvinder Singh32, Staplin Natalie2425, Stone John H.5152, Strohbehn Garth W.53, Sunden-Cullberg Jonas54, Torre-Cisneros Julian55, Tsai Larry W.41, van Hoogstraten Hubert56, van Meerten Tom57, Veiga Viviane Cordeiro14, Westerweel Peter E.58, Murthy Srinivas59, Diaz Janet V.60, Marshall John C.61, Sterne Jonathan A. C.5662
Affiliation:
1. The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group 2. Guy’s and St Thomas’ NHS Foundation Trust, ICU Support Offices, St Thomas’ Hospital, London, England 3. School of Immunology and Microbial Sciences, Kings College London, London, England 4. University College London, MRC Clinical Trials Unit at UCL, London, England 5. Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, England 6. NIHR Bristol Biomedical Research Centre, Bristol, England 7. National Institute for Health Research Applied Research Collaboration West at University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, England 8. University of Bristol, Bristol, England 9. Assistance Publique–Hôpitaux de Paris, Centre for Clinical Epidemiology, Hôpital Hôtel-Dieu, Paris, France 10. INSERM UMRS-1153, Centre de Recherche Epidémiologie et Statistique Université de Paris, METHODS Team, Paris, France 11. Department of Nursing, Hadassah Hebrew University Medical Center, Jerusalem, Israel 12. Berry Consultants, Austin, Texas 13. Turku University Hospital, Department of Infectious Diseases, Turku, Finland 14. BP-A Beneficência Portuguesa de São Paulo, Rua Maestro Cardim, São Paulo, Brazil 15. Department of Public Health and Primary Care, Ghent University, Ghent, Belgium 16. Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, the Netherlands 17. Department of Infectious Diseases, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain 18. Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia 19. Infectious Diseases Unit, Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain 20. Department of Pulmonary Diseases, Turku University Hospital, Turku, Finland 21. Infectious Diseases Department, Hospital Clinic Barcelona-IDIBAPS, Barcelona, Spain 22. Rheumatology, Hospital Universitario La Princesa IIS-IP, Madrid, Spain 23. Division of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, England 24. Nuffield Department of Population Health, University of Oxford, Oxford, England 25. MRC Population Health Research Unit, University of Oxford, Oxford, England 26. Department of Hematology, Necker Hospital, Paris, France 27. Imagine Institute, University of Paris, INSERM U1153, Paris, France 28. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, England 29. International Severe Acute Respiratory and Emerging Infections Consortium, University of Oxford, Oxford, England 30. Pandemic Sciences Centre, University of Oxford, Oxford, England 31. Department of Medicine, Massachusetts General Hospital, Boston 32. Medanta-The Medicity, Institute of Liver Transplantation and Regenerative Medicine, Gurugram, India 33. Research Department, Medanta Institute of Education and Research, Gurugram, India 34. VIB Center for Inflammation Research, Ghent University, Ghent, Belgium 35. Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium 36. Regeneron Pharmaceuticals Inc, Tarrytown, New York 37. Centre for Immunology of Viral Infections and Autoimmune Diseases, Université Paris-Saclay, INSERM UMR1184, Le Kremlin-Bicêtre, Paris, France 38. Department of Rheumatology, Assistance Publique–Hôpitaux de Paris, Le Le Kremlin-Bicêtre, Paris, France 39. Unit of Infectious Diseases and Microbiology, Valme University Hospital, Institute of Biomedicine of Sevilla, Seville, Spain 40. Hospital Sungai Buloh, Ministry of Health, Buloh, Malaysia 41. Genentech, South San Francisco, California 42. Hospital Universitario Ramón y Cajal IRYCIS, Infectious Diseases Department, Madrid, Spain 43. Department of Anesthesilogy Critical Care and Pain Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel 44. University de Paris, CRESS UMR1153, INSERM, INRA, Paris, France 45. Department of Rheumatology and Clinical Immunology, University Hospital Groningen, University Medical Center Groningen, Groningen, the Netherlands 46. Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia 47. Department of Paediatric Rheumatology, University Hospitals Bristol, NHS Foundation Trust, Bristol, England 48. Department of Medicine (Rheumatology), University of Chicago Medical Center, Chicago, Illinois 49. Department of Clinical Pharmacology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain 50. Center for Outcomes Research and Evaluation, Queen’s Medical Center, Honolulu, Hawaii 51. Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston 52. Department of Medicine (Rheumatology), Massachusetts General Hospital, Boston 53. VA Ann Arbor, Center for Clinical Management and Research, Ann Arbor, Michigan 54. Department of Infectious Diseases, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden 55. Maimonides Institute for Biomedical Research of Cordoba/Reina Sofia University Hospital/University of Córdoba, Córdoba, Spain 56. Global Medical Affairs, Sanofi-Genzyme, Bridgewater, New Jersey 57. Department of Hematology, University Medical Center Groningen, Groningen, the Netherlands 58. Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, the Netherlands 59. Department of Pediatrics, University of British Columbia, Vancouver, Canada 60. Clinical Unit, Health Emergencies Programme, World Health Organization, Geneva, Switzerland 61. Li Ka Shing Knowledge Institute, St Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada 62. Health Data Research UK South-West, Bristol, England
Publisher
American Medical Association (AMA)
Cited by
487 articles.
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