Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity Outcomes

Author:

Xia Shengli1,Duan Kai2,Zhang Yuntao3,Zhao Dongyang1,Zhang Huajun4,Xie Zhiqiang1,Li Xinguo2,Peng Cheng4,Zhang Yanbo5,Zhang Wei1,Yang Yunkai3,Chen Wei2,Gao Xiaoxiao4,You Wangyang1,Wang Xuewei3,Wang Zejun2,Shi Zhengli4,Wang Yanxia1,Yang Xuqin3,Zhang Lianghao2,Huang Lili1,Wang Qian3,Lu Jia2,Yang Yongli6,Guo Jing2,Zhou Wei2,Wan Xin2,Wu Cong2,Wang Wenhui2,Huang Shihe2,Du Jianhui2,Meng Ziyan2,Pan An57,Yuan Zhiming4,Shen Shuo2,Guo Wanshen1,Yang Xiaoming23

Affiliation:

1. Henan Center for Disease Control and Prevention, Zhengzhou, Henan, China

2. National Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Co Ltd, Wuhan, Hubei, China

3. China National Biotec Group Company Limited, Beijing, China

4. Chinese Academy of Sciences Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China

5. Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

6. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China

7. National Medical Center for Major Public Health Events, Huazhong University of Science and Technology, Wuhan, Hubei, China

Publisher

American Medical Association (AMA)

Subject

General Medicine

Reference34 articles.

1. Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial.;Zhu;Lancet,2020

2. Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial.;Zhu;Lancet

3. An mRNA vaccine against SARS-CoV-2 - preliminary report.;Jackson;N Engl J Med

4. Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial.;Folegatti;Lancet

5. Key steps in vaccine development.;Stern;Ann Allergy Asthma Immunol,2020

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