1. Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
2. Clinical Research Unit, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
3. Department of Anesthesiology and Perioperative Medicine, Ningbo No. 6 Hospital, Ningbo, Zhejiang, China
4. Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Wenzhou Medical University, The First Provincial Wenzhou Hospital of Zhejiang, Wenzhou, Zhejiang, China
5. Nottingham Clinical Trials Unit, University of Nottingham, Nottingham, United Kingdom
6. Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom
7. Department of Anesthesiology and Perioperative Medicine, Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang, China
8. Warwick Clinical Trials Unit, University of Warwick, Warwick, United Kingdom
9. University Hospitals of Birmingham NHS Foundation Trust, Birmingham, United Kingdom
10. Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom
11. Department of Anesthesia and Critical Care, Lishui Municipal People’s Hospital, Lishui Central Hospital, and Fifth Affiliated Hospital of Wenzhou Medical College, Lishui, Zhejiang, China
12. Department of Anesthesia and Critical Care, Lishui City People's Hospital, Lishui, Zhejiang, China
13. Department of Anesthesia and Critical Care, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China
14. for the RAGA Study Investigators