Effect of Metformin vs Placebo on Invasive Disease–Free Survival in Patients With Breast Cancer

Author:

Goodwin Pamela J.1,Chen Bingshu E.2,Gelmon Karen A.3,Whelan Timothy J.4,Ennis Marguerite5,Lemieux Julie6,Ligibel Jennifer A.7,Hershman Dawn L.8,Mayer Ingrid A.9,Hobday Timothy J.10,Bliss Judith M.11,Rastogi Priya12,Rabaglio-Poretti Manuela13,Mukherjee Som D.14,Mackey John R.15,Abramson Vandana G.9,Oja Conrad3,Wesolowski Robert16,Thompson Alastair M.17,Rea Daniel W.18,Stos Paul M.2,Shepherd Lois E.2,Stambolic Vuk1920,Parulekar Wendy R.2

Affiliation:

1. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

2. Canadian Cancer Trials Group, Queen’s University, Kingston, Ontario, Canada

3. Department of Medicine, University of British Columbia, BC Cancer Agency, Vancouver, Canada

4. Department of Radiation Oncology, McMaster University, Juravinski Cancer Centre, Hamilton, Ontario, Canada

5. Applied Statistician, Markham, Ontario, Canada

6. Department of Hematology Research, CHU de Québec-Université Laval, Québec, Québec, Canada

7. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts

8. Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York

9. Department of Medicine, Vanderbilt University, Nashville, Tennessee

10. Department of Oncology, Mayo Clinic, Rochester, Minnesota

11. Division of Clinical Studies, ICR-CTSU, Institute of Cancer Research United Kingdom, London, United Kingdom

12. Department of Medicine, NRG Oncology and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

13. Department of Medical Oncology, IBCSG and Department of Oncology, Bern University Hospital, University of Bern, Berne, Switzerland

14. Department of Oncology, Juravinski Cancer Center, McMaster University, Hamilton, Ontario, Canada

15. Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Canada

16. Department of Internal Medicine, James Cancer Hospital, Ohio State Comprehensive Cancer Center, Columbus, Ohio

17. Department of Surgery, Baylor College of Medicine, Houston, Texas

18. School of Cancer and Genomic Science, Cancer Research UK Clinical Trials Unit (CRCTU), Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom

19. Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

20. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

Publisher

American Medical Association (AMA)

Subject

General Medicine

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