Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection-Reference-Cited by-同舟云学术

Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection

Published:2023-06-13 Issue:22 Volume:329 Page:1934
ISSN:0098-7484
Container-title:JAMA
language:en
Short-container-title:JAMA

Author:

Thaweethai Tanayott¹²,Jolley Sarah E.³,Karlson Elizabeth W.⁴,Levitan Emily B.⁵,Levy Bruce²⁴,McComsey Grace A.⁶,McCorkell Lisa⁷,Nadkarni Girish N.⁸,Parthasarathy Sairam⁹,Singh Upinder¹⁰,Walker Tiffany A.¹¹,Selvaggi Caitlin A.¹,Shinnick Daniel J.¹,Schulte Carolin C. M.¹,Atchley-Challenner Rachel¹²,Horwitz Leora I.¹³,Foulkes Andrea S.¹²,Aberg Judith A.¹⁴,Adolphi Natalie L.¹⁴,Ahirwar Shreya¹⁴,Ahmed Shifa¹⁴,Ahuja Neera¹⁴,Aikawa Masanori¹⁴,Akerlundh Almary¹⁴,Akintonwa Teresa T.¹⁴,Al-Jadiri Aseel¹⁴,Alekhina Natalya¹⁴,Algren Heather A.¹⁴,Alshawabkeh Akram N.¹⁴,Ammar Nariman¹⁴,Anand Adit¹⁴,Anderson Brett R.¹⁴,Aponte-Soto Lisa¹⁴,Aschner Judy L.¹⁴,Atha Mary M.¹⁴,Atz Andrew M.¹⁴,Aupperle Robin L.¹⁴,Ayache Mirna¹⁴,Azziz-Baumgartner Eduardo¹⁴,Bailey L. C.¹⁴,Baker Fiona C.¹⁴,Balaraman Venkataraman¹⁴,Bandy Jennifer A.¹⁴,Banerjee Dithi¹⁴,Barch Deanna M.¹⁴,Bardes James M.¹⁴,Barlocker Jackson¹⁴,Barr R. G.¹⁴,Baskin-Sommers Arielle¹⁴,Basu Sanjib¹⁴,Battaglia Tracy A.¹⁴,Baucom Leah¹⁴,Beamon Carmen J.¹⁴,Beaty Casey L.¹⁴,Beckmann Noam D.¹⁴,Berry Jasmine A.¹⁴,Bhadelia Nahid¹⁴,Bhargava Daksh¹⁴,Bhuiyan Sultana¹⁴,Bian Jiang¹⁴,Bime Christian¹⁴,Bjork James M.¹⁴,Black Lora J.¹⁴,Blish Catherine A.¹⁴,Block Jason P.¹⁴,Bogie Amanda¹⁴,Bolliger Dawn¹⁴,Bonaventura William¹⁴,Bose-Brill Seuli¹⁴,Bower Mary B.¹⁴,Boyd Andrew D.¹⁴,Boyineni Jerusha¹⁴,Bradfute Steven B.¹⁴,Bramante Carolyn T.¹⁴,Brannock M. D.¹⁴,Bremner J. D.¹⁴,Brosnahan Shari B.¹⁴,Buchbinder Natalie C.¹⁴,Bueler Elliott¹⁴,Buhimschi Irina A.¹⁴,Bukulmez Hulya¹⁴,Bunnell H. T.¹⁴,Buse John B.¹⁴,Calhoun Elizabeth A.¹⁴,Cao Tingyi¹⁴,Carrithers Michael D.¹⁴,Carton Thomas W.¹⁴,Case Abigail¹⁴,Casey B.J.¹⁴,Casimero Faye Victoria C.¹⁴,Castro Lauren¹⁴,Cato Teresa¹⁴,Ceger Patricia¹⁴,Cerullo Connie L.¹⁴,Chang Linda¹⁴,Chang Arunee A.¹⁴,Chebrolu Praneeth¹⁴,Chen Yong¹⁴,Chen Li Qing¹⁴,Chen Benjamin K.¹⁴,Chestek David¹⁴,Chew Robert F.¹⁴,Chisolm Deena J.¹⁴,Chow Dominic C.¹⁴,Chrisant Maryanne R.¹⁴,Christakis Dimitri A.¹⁴,Chute Christopher G.¹⁴,Cicek Mine S.¹⁴,Clark Cheryl R.¹⁴,Clark Duncan B.¹⁴,Clarke Geoffrey D.¹⁴,Clouser Katharine N.¹⁴,Connors Thomas J.¹⁴,Cook Judith A.¹⁴,Coombs Krista¹⁴,Cordon-Cardo Carlos¹⁴,Costello Julie L.¹⁴,Cottrell Lesley¹⁴,Cowan Kelly¹⁴,Cowell Lindsay G.¹⁴,Cranford Savannah¹⁴,Cronin Jamie¹⁴,Cummins Mollie R.¹⁴,Curry Hannah L.¹⁴,D'Sa Viren¹⁴,Dabney Sean G.¹⁴,Daniel Casey L.¹⁴,Dapretto Mirella¹⁴,Darbar Dawood¹⁴,Darden Paul M.¹⁴,Dasgupta Raktima¹⁴,Dasgupta Soham¹⁴,Davis Blakley Felicia¹⁴,Dea Katherine¹⁴,Deakyne Davies Sara J.¹⁴,Decker Lauren A.¹⁴,DeFronzo Ralph A.¹⁴,Dehority Walter¹⁴,Deitchman Amelia N.¹⁴,del Alcazar James¹⁴,Del Boccio Phoebe¹⁴,del Rio Carlos¹⁴,Del Rios Marina¹⁴,DeLisa Julie A.¹⁴,Deoni Sean C.¹⁴,Diaz Maya Z.¹⁴,Dickinson John D.¹⁴,Dionne Audrey¹⁴,Diviak Kathleen R.¹⁴,Donohue Sarah E.¹⁴,Downey Michael J.¹⁴,Dozor Allen J.¹⁴,Dreyer Benard P.¹⁴,Dummer Kirsten B.¹⁴,Durstenfeld Matthew S.¹⁴,Dworkin Mark S.¹⁴,Edmonds Sherrie L.¹⁴,Elias Matthew D.¹⁴,Elifritz Jamie¹⁴,Ellingworth Evan¹⁴,Elliott Amy J.¹⁴,Ellison Angela M.¹⁴,Enger Mike L.¹⁴,Espinosa Joaquin M.¹⁴,Esquenazi-Karonika Shari¹⁴,Evans Michael D.¹⁴,Evans Danielle N.¹⁴,Facelli Julio C.¹⁴,Fang Camila S.¹⁴,Faustino E. Vincent S.¹⁴,Fayad Lara Maria E.¹⁴,Feldman Candace H.¹⁴,Fiks Alexander G.¹⁴,Fineman Rebecca¹⁴,Finn Aloke V.¹⁴,Fischer Melinda S.¹⁴,Fitzgerald Megan L.¹⁴,Flaherman Valerie J.¹⁴,Flotte Thomas J.¹⁴,Forsha Daniel¹⁴,Fortune Meghan R.¹⁴,Foxe John J.¹⁴,Franks Nicole¹⁴,Freedman Michael B.¹⁴,Freeland Catherine E.¹⁴,Friedman Naomi P.¹⁴,Fry Greta¹⁴,Gage Witvliet Margot¹⁴,Gallagher Emily J.¹⁴,Gallagher Richard¹⁴,Garavan Hugh¹⁴,Gaur Sunanda M.¹⁴,Gee Dylan G.¹⁴,Gennaro Maria Laura¹⁴,Gerald Lynn B.¹⁴,Ghosh Saikat B.¹⁴,Giacino Joseph T.¹⁴,Girvin Andrew T.¹⁴,Godfrey Stephanie L.¹⁴,Goldberg Mark P.¹⁴,Goodman Steven N.¹⁴,Gordon Howard S.¹⁴,Gouripeddi Ramkiran¹⁴,Graham Paige¹⁴,Granger Joey P.¹⁴,Gray Kevin M.¹⁴,Greimes Tina¹⁴,Gross Rachel S.¹⁴,Guthe Nicholas¹⁴,Gutter Evan¹⁴,Haasnoot Stephanie¹⁴,Hadley Emily C.¹⁴,Haendel Melissa A.¹⁴,Hafner Stephanie¹⁴,Halabi Katia C.¹⁴,Hanley Patrick C.¹⁴,Harahsheh Ashraf S.¹⁴,Harkins Michelle S.¹⁴,Hartwig Kimberly L.¹⁴,Hasbani Keren¹⁴,Hasek Sharon¹⁴,Hauser Kristine S.¹⁴,Heath Andrew C.¹⁴,Hebson Camden L.¹⁴,Heitzeg Mary M.¹⁴,Hendrickson Monica¹⁴,Henrich Timothy J.¹⁴,Hernandez-Romieu Alfonso C.¹⁴,Hester Christina M.¹⁴,Higginbotham Miranda¹⁴,Hill Sophia¹⁴,Hirabayashi Kathryn¹⁴,Ho On¹⁴,Hobart-Porter Laura¹⁴,Hoffman M. C.¹⁴,Holtcamp Maryann¹⁴,Hong Travis K.¹⁴,Horne Benjamin D.¹⁴,Horowitz Carol R.¹⁴,Hsia Daniel S.¹⁴,Hsu Harvey¹⁴,Hsue Priscilla Y.¹⁴,Huentelman Matthew¹⁴,Huerta Bryan E.¹⁴,Huling Jared D.¹⁴,Hummel Kathy¹⁴,Iacono William G.¹⁴,Ibanez Alejandra L.¹⁴,Ibeawuchi Carmel¹⁴,Irby Katherine¹⁴,Ismail Nahed¹⁴,Jacobus Joanna¹⁴,Jacoby Vanessa L.¹⁴,Jason Leonard A.¹⁴,Javia Vidhi¹⁴,Jennette Kyle J.¹⁴,Jernigan Terry L.¹⁴,Jiang Sihang¹⁴,Jing Naimin¹⁴,Johnny Jace D.¹⁴,Johnson Nadia¹⁴,Johnson Brandi¹⁴,Johnson Brandon¹⁴,Jone Pei-Ni¹⁴,Judd Suzanne E.¹⁴,Juskowich Joy J.¹⁴,Kabagambe Edmond K.¹⁴,Kaelber David C.¹⁴,Kanjilal Diane G.¹⁴,Kansal Mayank M.¹⁴,Kasmarcak Tyler J.¹⁴,Kaufman Daniel¹⁴,Kawakami Rika¹⁴,Kellogg Dean L.¹⁴,Kent Denise A.¹⁴,Kewlani Deepshikha¹⁴,Khullar Dhruv¹⁴,Kim Keri S.¹⁴,Kim Arthur Y.¹⁴,Kinser Patricia A.¹⁴,Kleinman Lawrence C.¹⁴,Klerman Elizabeth B.¹⁴,Kluko Matthew J.¹⁴,Knight Stacey¹⁴,Kobayashi Misaki¹⁴,Kopp Karla J.¹⁴,Koropsak Michael¹⁴,Kosut Jessica S.¹⁴,Kraig Ellen¹⁴,Krausert Amanda¹⁴,Krieger Ana C.¹⁴,Krishna Hema¹⁴,Krishnamoorthy Aparna¹⁴,Krishnan Sankaran S.¹⁴,Lahs James P.¹⁴,Laird Angela R.¹⁴,Laleau Victoria¹⁴,Lamendola-Essel Michelle F.¹⁴,Landeo-Gutierrez Jeremy¹⁴,Lang Sean M.¹⁴,Larson Christine L.¹⁴,Lash James P.¹⁴,Lasky-Su Jessica¹⁴,Laynor Gregory¹⁴,Lee Simon¹⁴,Lee Grace M.¹⁴,Lee F. E.¹⁴,Lee Matthew A.¹⁴,Leese Peter J.¹⁴,Lefebvre R. C.¹⁴,Levreault Angelica J.¹⁴,Lewis Kennedy C.¹⁴,Li Lu¹⁴,Lim Peter Paul C.¹⁴,Lin Janet Y.¹⁴,Lisdahl Krista M.¹⁴,Litvack Matthew B.¹⁴,Liu Xiaokang¹⁴,Lloyd Jennifer¹⁴,Logue Jennifer K.¹⁴,Loomba Johanna J.¹⁴,Lorman Vitaly¹⁴,Lu Yiwen¹⁴,Ludwig Katelyn R.¹⁴,Lutz Allison M.¹⁴,Mack Jeri¹⁴,Mahmoud Abeer M.¹⁴,Maier Cheryl L.¹⁴,Malakooti Shahdi K.¹⁴,Malchenko Sergey¹⁴,Mallett Gail L.¹⁴,Maranga Gabrielle¹⁴,Martel Megan W.¹⁴,Martin-Herz Susanne P.¹⁴,Martinez-Lage Maria¹⁴,Maughan Christine¹⁴,Mauntel-Medici Cammeo¹⁴,May Heidi T.¹⁴,Mayer Kenneth H.¹⁴,Mazzotti Diego R.¹⁴,McCallum Caitryn M.¹⁴,McCrindle Brian W.¹⁴,McCulloh Russell J.¹⁴,McDonald Dylan¹⁴,McInnis Stephanie¹⁴,McMurry Julie A.¹⁴,Mejias Asuncion¹⁴,Melamed Jonathan¹⁴,Menchaca Martha¹⁴,Mendelsohn Alan L.¹⁴,Miele Lucio¹⁴,Miglis Mitchell G.¹⁴,Milne Cris¹⁴,Milner Joshua D.¹⁴,Mitchell Roger A.¹⁴,Mittleman Murray A.¹⁴,Mohandas Sindhu¹⁴,Monteiro Jonathan G.¹⁴,Monzon Vanessa¹⁴,Moreno David J.¹⁴,Morgan Lerraughn M.¹⁴,Morozyuk Dmitry¹⁴,Morse Keith E.¹⁴,Moyneur Erick¹⁴,Mudumbi Praveen C.¹⁴,Müller-Oehring Eva M.¹⁴,Muramatsu Naoko¹⁴,Musick Hugh¹⁴,Nagavedu Kshema¹⁴,Nahin Erica R.¹⁴,Nambiar Anoop M.¹⁴,Natelson Benjamin H.¹⁴,Neale Michael C.¹⁴,Ness-Cochinwala Manette¹⁴,Newburger Jane W.¹⁴,Newman Lisa T.¹⁴,Nguyen Amber N.¹⁴,Nichols Lauren¹⁴,Nolan Sheila M.¹⁴,Noland Seth¹⁴,Novak Richard M.¹⁴,O'Connor George T.¹⁴,O'Keefe John J.¹⁴,Ogbogu Princess U.¹⁴,Oliveira Carlos R.¹⁴,Oster Matthew E.¹⁴,Padera Robert F.¹⁴,Paik Henry H.¹⁴,Pajor Nathan M.¹⁴,Pan Huaqin Helen¹⁴,Pant Deepti¹⁴,Partridge Andrew¹⁴,Patel Payal B.¹⁴,Patel Saaya¹⁴,Patel Khushboo¹⁴,Paulus Martin P.¹⁴,Payne Ronald M.¹⁴,Pearman Ann¹⁴,Peralta-Carcelen Myriam¹⁴,Perez Nicolas L.¹⁴,Pfaff Emily R.¹⁴,Pillers De-Ann M.¹⁴,Pitsch Chloe E.¹⁴,Pliskin Neil H.¹⁴,Portman Michael A.¹⁴,Postelnicu Radu¹⁴,Potter Jennifer S.¹⁴,Prabhakar Bellur S.¹⁴,Prahalad Priya¹⁴,Prasad Bharati¹⁴,Predki Barbara¹⁴,Preiss Alexander J.¹⁴,Prendergast Heather M.¹⁴,Quinn Davin K.¹⁴,Quintana Yuri¹⁴,Rabideau Dustin J.¹⁴,Radosta Jonathan M.¹⁴,Radwell Jeffrey¹⁴,Raissy Hengameh¹⁴,Ramchandran Ramaswamy¹⁴,Randall Isabelle¹⁴,Rao Suchitra¹⁴,Rapkiewicz Amy¹⁴,Rasmussen Sonja A.¹⁴,Razzaghi Hanieh¹⁴,Rebello Candida J.¹⁴,Rebolledo Paulina A.¹⁴,Reddy Neha V.¹⁴,Reddy Unma M.¹⁴,Reedy Cara¹⁴,Rehman Jalees¹⁴,Reichard R. R.¹⁴,Reid Kayleigh M.¹⁴,Reusch Jane E.¹⁴,Rhee Kyung E.¹⁴,Rice Mary B.¹⁴,Rizzo John-Ross R.¹⁴,Roan Nadia R.¹⁴,Robarts Polly¹⁴,Roberts Timothy R.¹⁴,Rochez Nitza¹⁴,Rodgers Kathleen E.¹⁴,Rogerson Colin M.¹⁴,Romero Maria E.¹⁴,Rosas Johana M.¹⁴,Rosenzweig Erika B.¹⁴,Rothman Russell L.¹⁴,Rouphael Nadine G.¹⁴,Russell Mark W.¹⁴,Rutherfoord Melissa¹⁴,Sabati Arash A.¹⁴,Sader Samer B.¹⁴,Salehi Marzieh¹⁴,Salisbury Amy L.¹⁴,Sampson Barbara A.¹⁴,Sanil Yamuna¹⁴,Sato Alice I.¹⁴,Saydah Sharon H.¹⁴,Schechter Michael S.¹⁴,Schenck Edward J.¹⁴,Schlepphorst Katherine I.¹⁴,Schuchard Julia¹⁴,Schuh Tina L.¹⁴,Sculley Jennifer A.¹⁴,Seifert Alan C.¹⁴,Sekar Anisha K.¹⁴,Selvarangan Rangaraj¹⁴,Seshadri Sudha¹⁴,Sesso Howard D.¹⁴,Shah Dimpy P.¹⁴,Shakti Divya¹⁴,Shapiro Nancy L.¹⁴,Sharma Suchetha¹⁴,Sharma Kumar¹⁴,Sharma Shubhi¹⁴,Sharma Kavita¹⁴,Shaw Gwendolyn¹⁴,Shemesh Eyal¹⁴,Shen Yishan¹⁴,Shenkman Elizabeth¹⁴,Shiau Stephanie¹⁴,Siciliano Michelle¹⁴,Simsir Aylin¹⁴,Smith Veronica E.¹⁴,Snowden Jessica N.¹⁴,Solomon Isaac H.¹⁴,Spikes Leslie A.¹⁴,Squeglia Lindsay M.¹⁴,Srivastava Shubhika¹⁴,St. Jean Mary L.¹⁴,Stapleford Kenneth A.¹⁴,Stein Cheryl R.¹⁴,Stevenson Michelle D.¹⁴,Stewart de Ramirez Sarah A.¹⁴,Stiles Lauren E.¹⁴,Stock Aryeh¹⁴,Stockwell Melissa S.¹⁴,Stone James R.¹⁴,Stratford Jeran¹⁴,Stürmer Til¹⁴,Subbian Vignesh¹⁴,Sun Jun¹⁴,Suthar Mehul S.¹⁴,Sylvera Ashley¹⁴,Systrom David M.¹⁴,Szmuszkovicz Jacqueline¹⁴,Talavera-Barber Maria M.¹⁴,Tantisira Kelan G.¹⁴,Tartt Nancy¹⁴,Terlinde Tracy¹⁴,Teufel Ronald J.¹⁴,Thacker Deepika¹⁴,Thakrar Mansi¹⁴,Thibodeau Stephen N.¹⁴,Thomas Gelise L.¹⁴,Thomason Moriah E.¹⁴,Tong Jiayi¹⁴,Torres Robert¹⁴,Traenkner Jessica¹⁴,Tragus Robin¹⁴,Trinity Joel D.¹⁴,Tronieri Jena S.¹⁴,Troxel Andrea B.¹⁴,Truong Jennifer¹⁴,Truong Dongngan T.¹⁴,Tsevat Joel¹⁴,Udosen Mmekom M.¹⁴,Unterberger Kristen¹⁴,Utz Paul J.¹⁴,Vaccarino Viola¹⁴,Vallejos Brittany B.¹⁴,Vanden Hoek Terry L.¹⁴,Vangeepuram Nita¹⁴,Varma Jay K.¹⁴,Vernon Suzanne D.¹⁴,Vidal Crystal M.¹⁴,Vivensi Sara¹⁴,Vohra Adam S.¹⁴,Wagner Laura K.¹⁴,Wang Fei¹⁴,Warburton David¹⁴,Warner Megan R.¹⁴,Watkins Rebecca L.¹⁴,Watson Sara E.¹⁴,Webb Ryan¹⁴,Weeks Ryan M.¹⁴,Weiner Mark G.¹⁴,Werzberger Alan¹⁴,West Shelby C.¹⁴,Weyer Jordan C.¹⁴,Wheeler Jennifer L.¹⁴,Wilkins Kenneth J.¹⁴,Williams Natasha J.¹⁴,Williams Charles T.¹⁴,Wimberly Erika S.¹⁴,Winter Terra J.¹⁴,Woller Scott C.¹⁴,Wong Rachel¹⁴,Wood Jeremy P.¹⁴,Wood John C.¹⁴,Wood Marion J. J.¹⁴,Wu Qiong¹⁴,Xia Yinglin¹⁴,Xu Jie¹⁴,Yang Samuel¹⁴,Yin H. S.¹⁴,Yin Hsiang S.¹⁴,Yoo Yun Jae¹⁴,Young Chloe E.¹⁴,Young Natalie M.¹⁴,Zang Chengxi¹⁴,Zempsky William T.¹⁴,Zhang Bingyu¹⁴,Zhang Yongkang¹⁴,Zhang Dazheng¹⁴,Zimmerman Emily¹⁴,Alba George A.¹,Alicic Radica¹⁵,Altman Natasha³,Anglin Khamal¹⁶,Argueta Urania¹⁶,Ashktorab Hassan¹⁷,Baslet Gaston⁴,Bassett Ingrid V.¹,Bateman Lucinda¹⁸,Bedi Brahmchetna¹¹,Bhattacharyya Shamik⁴,Bind Marie-Abele¹,Blomkalns Andra L.¹⁹,Bonilla Hector¹⁹,Bush Patricia A.²⁰,Castro Mario²¹,Chan James¹,Charney Alexander W.⁸,Chen Peter²²,Chibnik Lori B.¹,Chu Helen Y.²³,Clifton Rebecca G.²⁴,Costantine Maged M.²⁵,Cribbs Sushma K.¹¹,Davila Nieves Sylvia I.²⁶,Deeks Steven G.¹⁶,Duven Alexandria²⁷,Emery Ivette F.²⁸,Erdmann Nathan⁵,Erlandson Kristine M.³,Ernst Kacey C.²⁹,Farah-Abraham Rachael³⁰,Farner Cheryl E.³¹,Feuerriegel Elen M.³,Fleurimont Judes³²,Fonseca Vivian³³,Franko Nicholas¹⁵,Gainer Vivian³⁴,Gander Jennifer C.³⁵,Gardner Edward M.³⁶,Geng Linda N.¹⁹,Gibson Kelly S.³⁷,Go Minjoung¹⁰,Goldman Jason D.²⁷,Grebe Halle¹⁶,Greenway Frank L.³⁸,Habli Mounira³⁹,Hafner John⁴⁰,Han Jenny E.¹¹,Hanson Keith A.⁴¹,Heath James⁴²,Hernandez Carla⁴³,Hess Rachel⁴⁴,Hodder Sally L.⁴⁵,Hoffman Matthew K.⁴⁶,Hoover Susan E.⁴⁷,Huang Beatrice¹⁶,Hughes Brenna L.⁴⁸,Jagannathan Prasanna¹⁹,John Janice⁴⁹,Jordan Michael R.⁵⁰,Katz Stuart D.¹³,Kaufman Elizabeth S.⁵¹,Kelly John D.¹⁶,Kelly Sara W.⁴¹,Kemp Megan M.¹⁵,Kirwan John P.³⁸,Klein Jonathan D.³²,Knox Kenneth S.⁵²,Krishnan Jerry A.⁵³,Kumar Andre¹⁰,Laiyemo Adeyinka O.⁵⁴,Lambert Allison A.¹⁵,Lanca Margaret²,Lee-Iannotti Joyce K.⁵²,Logarbo Brian P.⁵⁵,Longo Michele T.⁵⁶,Luciano Carlos A.⁵⁷,Lutrick Karen²⁹,Maley Jason H.⁵⁸,Marathe Jai G.⁵⁹,Marconi Vincent³⁰,Marshall Gailen D.⁶⁰,Martin Christopher F.³⁰,Matusov Yuri²²,Mehari Alem⁵⁴,Mendez-Figueroa Hector⁶¹,Mermelstein Robin³²,Metz Torri D.⁶²,Morse Richard¹,Mosier Jarrod⁶³,Mouchati Christian⁶⁴,Mullington Janet²,Murphy Shawn N.¹,Neuman Robert B.²⁰,Nikolich Janko Z.²⁹,Ofotokun Ighovwerha¹¹,Ojemakinde Elizabeth⁶⁵,Palatnik Anna⁶⁶,Palomares Kristy⁶⁷,Parimon Tanyalak⁶⁸,Parry Samuel⁶⁹,Patterson Jan E.³¹,Patterson Thomas F.³¹,Patzer Rachel E.³⁰,Peluso Michael J.¹⁶,Pemu Priscilla⁶⁵,Pettker Christian M.⁷⁰,Plunkett Beth A.²⁷¹,Pogreba-Brown Kristen²⁹,Poppas Athena⁷²,Quigley John G.³²,Reddy Uma⁷³,Reece Rebecca⁷⁴,Reeder Harrison¹,Reeves W. B.⁷⁵,Reiman Eric M.⁷⁶,Rischard Franz⁷⁷,Rosand Jonathan¹,Rouse Dwight J.⁷⁸,Ruff Adam⁷⁹,Saade George⁸⁰,Sandoval Grecio J.⁸¹,Schlater Shannon M.⁶²,Shepherd Fitzgerald⁸²,Sherif Zaki A.⁵⁴,Simhan Hyagriv⁸³,Singer Nora G.³⁷,Skupski Daniel W.⁸⁴,Sowles Amber⁶²,Sparks Jeffrey A.⁴,Sukhera Fatima I.⁸⁵,Taylor Barbara S.³¹,Teunis Larissa³⁰,Thomas Robert J.⁵⁸,Thorp John M.⁸⁶,Thuluvath Paul⁸⁷,Ticotsky Amberly⁴⁹,Tita Alan T.⁸⁸,Tuttle Katherine R.¹⁵,Urdaneta Alfredo E.¹⁰,Valdivieso Daisy¹⁶,VanWagoner Timothy M.⁸⁹,Vasey Andrew⁹⁰,Verduzco-Gutierrez Monica³¹,Wallace Zachary S.¹,Ward Honorine D.⁵⁰,Warren David E.⁹⁰,Weiner Steven J.⁹¹,Welch Shelley⁹²,Whiteheart Sidney W.⁹³,Wiley Zanthia³⁰,Wisnivesky Juan P.⁸,Yee Lynn M.⁹⁴,Zisis Sokratis⁶, ,

Affiliation:

1. Massachusetts General Hospital, Boston

2. Harvard Medical School, Boston, Massachusetts

3. University of Colorado Anschutz Medical Campus, Aurora

4. Brigham and Women’s Hospital, Boston, Massachusetts

5. University of Alabama at Birmingham

6. Case Western Reserve University, Cleveland, Ohio

7. Patient-Led Research Collaborative, Calabasas, California

8. Icahn School of Medicine at Mount Sinai, New York, New York

9. The University of Arizona College of Medicine, Tucson

10. Stanford University School of Medicine, Stanford, California

11. Emory University School of Medicine, Atlanta, Georgia

12. Mass General Brigham, Boston, Massachusetts

13. New York University Grossman School of Medicine, New York

14. for the RECOVER Consortium

15. University of Washington, Seattle

16. University of California, San Francisco

17. Howard University, Washington, DC

18. Bateman Horne Center, Salt Lake City, Utah

19. Stanford University, Stanford, California

20. Kaiser Foundation Health Plan of Georgia Inc, Atlanta

21. University of Kansas Medical Center, Kansas City

22. Cedars-Sinai Medical Center, Los Angeles, California

23. University of Washington School of Medicine, Seattle

24. George Washington University, Washington, DC

25. The Ohio State University, Columbus

26. Universidad de Puerto Rico Recinto de Ciencias Medicas, San Juan, Puerto Rico

27. Swedish Medical Center, Seattle, Washington

28. MaineHealth, Portland

29. The University of Arizona, Tucson

30. Emory University, Atlanta, Georgia

31. The University of Texas Health Science Center at San Antonio

32. University of Illinois Chicago

33. Tulane University Health Sciences Center, New Orleans, Louisiana

34. Partners HealthCare Systems, Boston, Massachusetts

35. Kaiser Permanente Georgia, Atlanta

36. Denver Health, Denver, Colorado

37. MetroHealth Medical Center, Cleveland, Ohio

38. Pennington Biomedical Research Center, Baton Rouge, Louisiana

39. TriHealth, Cincinnati, Ohio

40. University of Illinois Chicago College of Medicine

41. University of Illinois College of Medicine at Peoria

42. Institute for Systems Biology, Seattle, Washington

43. UH Cleveland Medical Center, Cleveland, Ohio

44. University of Utah Schools of the Health Sciences, Salt Lake City

45. West Virginia Clinical and Translational Science Institute, Morgantown

46. Christiana Care Health Services Inc, Newark, Delaware

47. Sanford Health, Sioux Falls, South Dakota

48. Duke University, Durham, North Carolina

49. Cambridge Health Alliance, Cambridge, Massachusetts

50. Tufts Medical Center, Boston, Massachusetts

51. MetroHealth Campus of Case Western Reserve University, Cleveland, Ohio

52. The University of Arizona College of Medicine, Phoenix

53. University of Illinois Hospital and Health Sciences System, Chicago

54. Howard University College of Medicine, Washington, DC

55. Tulane University, New Orleans, Louisiana

56. Tulane School of Medicine, New Orleans, Louisiana

57. Universidad de Puerto Rico, San Juan, Puerto Rico

58. Beth Israel Deaconess Medical Center, Boston, Massachusetts

59. Boston University, Boston, Massachusetts

60. University of Mississippi, Oxford

61. McGovern Medical School at The University of Texas Health Science Center at Houston

62. University of Utah Health, Salt Lake City

63. University of Arizona, Tucson

64. Case Western Reserve University School of Medicine, Cleveland, Ohio

65. Morehouse School of Medicine, Atlanta, Georgia

66. Medical College of Wisconsin, Milwaukee

67. Saint Peter’s University Hospital, Brunswick, New Jersey

68. Cedars-Sinai Health System, Los Angeles, California

69. University of Pennsylvania, Philadelphia

70. Yale School of Medicine, New Haven, Connecticut

71. NorthShore University HealthSystem, Evanston, Illinois

72. Warren Alpert Medical School, Brown University, Providence, Rhode Island

73. Columbia University Irving Medical Center, New York, New York

74. West Virginia University School of Medicine, Morgantown

75. Department of Medicine, The University of Texas Health Science Center at San Antonio

76. Banner Alzheimer’s Institute, Phoenix, Arizona

77. Banner University Medical Center Tucson, Arizona

78. Brown University, Providence, Rhode Island

79. The University of Kansas Medical Center, Kansas City

80. Eastern Virginia Medical School, Norfolk

81. Milken Institute of Public Health, The George Washington University, Washington, DC

82. Boston University School of Medicine, Boston, Massachusetts

83. University of Pittsburgh, Pittsburgh, Pennsylvania

84. Weill Cornell Medicine, New York, New York

85. The University of Oklahoma, Norman

86. The University of North Carolina at Chapel Hill

87. Mercy Medical Center, Baltimore, Maryland

88. University of Alabama, Birmingham

89. University of Oklahoma Health Sciences Center, Oklahoma City

90. University of Nebraska Medical Center, Omaha

91. The George Washington University Biostatistics Center, Rockville, Maryland

92. West Virginia University, Morgantown

93. University of Kentucky, Lexington

94. Feinberg School of Medicine, Northwestern University, Chicago, Illinois

Abstract

ImportanceSARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID. Characterizing PASC requires analysis of prospectively and uniformly collected data from diverse uninfected and infected individuals.ObjectiveTo develop a definition of PASC using self-reported symptoms and describe PASC frequencies across cohorts, vaccination status, and number of infections.Design, Setting, and ParticipantsProspective observational cohort study of adults with and without SARS-CoV-2 infection at 85 enrolling sites (hospitals, health centers, community organizations) located in 33 states plus Washington, DC, and Puerto Rico. Participants who were enrolled in the RECOVER adult cohort before April 10, 2023, completed a symptom survey 6 months or more after acute symptom onset or test date. Selection included population-based, volunteer, and convenience sampling.ExposureSARS-CoV-2 infection.Main Outcomes and MeasuresPASC and 44 participant-reported symptoms (with severity thresholds).ResultsA total of 9764 participants (89% SARS-CoV-2 infected; 71% female; 16% Hispanic/Latino; 15% non-Hispanic Black; median age, 47 years [IQR, 35-60]) met selection criteria. Adjusted odds ratios were 1.5 or greater (infected vs uninfected participants) for 37 symptoms. Symptoms contributing to PASC score included postexertional malaise, fatigue, brain fog, dizziness, gastrointestinal symptoms, palpitations, changes in sexual desire or capacity, loss of or change in smell or taste, thirst, chronic cough, chest pain, and abnormal movements. Among 2231 participants first infected on or after December 1, 2021, and enrolled within 30 days of infection, 224 (10% [95% CI, 8.8%-11%]) were PASC positive at 6 months.Conclusions and RelevanceA definition of PASC was developed based on symptoms in a prospective cohort study. As a first step to providing a framework for other investigations, iterative refinement that further incorporates other clinical features is needed to support actionable definitions of PASC.

Publisher

American Medical Association (AMA)

Subject

General Medicine

Link

https://jamanetwork.com/journals/jama/articlepdf/2805540/jama_thaweethai_2023_oi_230062_1686240966.39381.pdf

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