Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer

Author:

,Goode Ellen L.1,Block Matthew S.2,Kalli Kimberly R.2,Vierkant Robert A.1,Chen Wenqian3,Fogarty Zachary C.1,Gentry-Maharaj Aleksandra4,Toloczko Aleksandra5,Hein Alexander6,Bouligny Aliecia L.17,Jensen Allan8,Osorio Ana910,Hartkopf Andreas D.11,Ryan Andy4,Chudecka-Glaz Anita12,Magliocco Anthony M.13,Hartmann Arndt14,Jung Audrey Y15,Gao Bo1617,Hernandez Brenda Y.18,Fridley Brooke L.19,McCauley Bryan M.1,Kennedy Catherine J.1620,Wang Chen1,Karpinskyj Chloe4,de Sousa Christiani B.21,Tiezzi Daniel G.21,Wachter David L.14,Herpel Esther22,Taran Florin Andrei11,Modugno Francesmary232425,Nelson Gregg26,Lubinski Jan5,Menkiszak Janusz12,Alsop Jennifer27,Lester Jenny28,García-Donas Jesús29,Nation Jill26,Hung Jillian1620,Palacios José30,Rothstein Joseph H.31,Kelley Joseph L.23,de Andrade Jurandyr M.21,Robles-Díaz Luis32,Intermaggio Maria P.33,Widschwendter Martin4,Beckmann Matthias W.6,Ruebner Matthias6,Jimenez-Linan Mercedes34,Singh Naveena35,Oszurek Oleg5,Harnett Paul R.1617,Rambau Peter F.336,Sinn Peter37,Wagner Philipp11,Ghatage Prafull26,Sharma Raghwa3839,Edwards Robert P.23,Ness Roberta B.40,Orsulic Sandra28,Brucker Sara Y.11,Johnatty Sharon E.41,Longacre Teri A.42,Eilber Ursula15,McGuire Valerie43,Sieh Weiva31,Natanzon Yanina1,Li Zheng144,Whittemore Alice S.45,deFazio Anna1620,Staebler Annette46,Karlan Beth Y.28,Gilks Blake47,Bowtell David D.484950,Høgdall Estrid851,Candido dos Reis Francisco J.21,Steed Helen52,Campbell Ian G.535455,Gronwald Jacek5,Benítez Javier910,Koziak Jennifer M.56,Chang-Claude Jenny1557,Moysich Kirsten B.58,Kelemen Linda E.59,Cook Linda S.60,Goodman Marc T.61,García María José910,Fasching Peter A.662,Kommoss Stefan11,Deen Suha63,Kjaer Susanne K.864,Menon Usha4,Brenton James D.656667,Pharoah Paul D. P.2768,Chenevix-Trench Georgia41,Huntsman David G.6970,Winham Stacey J.1,Köbel Martin3,Ramus Susan J.3350

Affiliation:

1. Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota

2. Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota

3. Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada

4. Gynaecological Cancer Research Centre, Department of Women’s Cancer, Institute for Women's Health, University College London, London, England

5. International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

6. Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University, Erlangen-Nuremberg Comprehensive Cancer Center, Erlangen EMN, Germany

7. Department of Health Sciences, Spelman College, Atlanta, Georgia

8. Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark

9. Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

10. Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain

11. Tübingen University Hospital, Department of Women's Health, Tübingen, Germany

12. Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland

13. Department of Anatomic Pathology, Moffitt Cancer Center, Tampa, Florida

14. Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany

15. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

16. Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia

17. The Crown Princess Mary Cancer Centre, Westmead Hospital, The University of Sydney, Australia

18. Cancer Center, University of Hawaii, Honolulu

19. Department of Biostatistics and Bioinformatics, Division of Population Sciences, Moffitt Cancer Center, Tampa, Florida

20. Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia

21. Department of Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil

22. Tissue Bank of the National Center for Tumor Diseases (NCT) Heidelberg, Germany and Institute of Pathology, University of Heidelberg, Heidelberg, Germany

23. Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

24. Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania

25. Women’s Cancer Research Program, Magee-Women’s Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania

26. Department of Oncology, Division of Gynecologic Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

27. Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, England.

28. Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California

29. Medical Oncology Service, HM Hospitales–Centro Integral Oncológico HM Clara Campal, Madrid, Spain

30. Department of Pathology, Hospital Universitario Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid, Spain

31. Department of Population Health Science and Policy and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York

32. Familial Cancer Unit and Medical Oncology Department, Hospital Universitario 12 de Octubre, Madrid, Spain

33. School of Women's and Children's Health, University of New South Wales, Sydney, Australia

34. Department of Histopathology, Addenbrookes Hospital, Cambridge, England

35. Department of Pathology, Barts Health National Health Service Trust, London, England

36. Department of Pathology, Catholic University of Health and Allied Sciences–Bugando, Mwanza, Tanzania

37. Department of Pathology, Institute of Pathology, Heidelberg University Hospital, Germany

38. Pathology West ICPMR Westmead, Westmead Hospital, The University of Sydney, Sydney, Australia

39. University of Western Sydney at Westmead Hospital, Westmead, New South Wales, Australia

40. University of Texas School of Public Health, Houston,

41. Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia

42. Department of Pathology, Stanford University, Stanford, California

43. Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California

44. Department of Gynecologic Oncology, The Third Affiliated Hospital of Kunming Medical University (Yunnan Tumor Hospital), Kunming, China

45. Department of Health Research and Policy and Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, California

46. Tübingen University Hospital, Institute of Pathology, Tübingen, Germany

47. Genetic Pathology Evaluation Centre, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada

48. Cancer Genomics Program, Research Department, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

49. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia

50. The Garvan Institute, Sydney, New South Wales, Australia

51. Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark

52. Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Royal Alexandra Hospital, Edmonton, Alberta, Canada

53. Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia

54. Sir Peter MacCallum Department of Oncology, University of Melbourne, Australia

55. Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia

56. Alberta Health Services–Cancer Care, Calgary, Alberta, Canada

57. University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

58. Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York

59. Department of Public Health Sciences, Medical University of South Carolina and Hollings Cancer Center, Charleston

60. Division of Epidemiology and Biostatistics, University of New Mexico, Albuquerque

61. Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California

62. David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles

63. Department of Histopathology, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, England

64. Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

65. Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, England

66. Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, England

67. Cambridge Experimental Cancer Medicine Centre, Cambridge, England

68. Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, England

69. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

70. Centre for Translational and Applied Genomics, British Columbia Cancer Agency, Vancouver, British Columbia, Canada

Publisher

American Medical Association (AMA)

Subject

Oncology,Cancer Research

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