Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer

Author:

Pearlman Rachel1,Frankel Wendy L.2,Swanson Benjamin2,Zhao Weiqiang2,Yilmaz Ahmet2,Miller Kristin2,Bacher Jason2,Bigley Christopher1,Nelsen Lori1,Goodfellow Paul J.3,Goldberg Richard M.1,Paskett Electra1,Shields Peter G.1,Freudenheim Jo L.4,Stanich Peter P.5,Lattimer Ilene1,Arnold Mark6,Liyanarachchi Sandya7,Kalady Matthew8,Heald Brandie8,Greenwood Carla9,Paquette Ian10,Prues Marla11,Draper David J.12,Lindeman Carolyn12,Kuebler J. Philip13,Reynolds Kelly14,Brell Joanna M.15,Shaper Amy A.16,Mahesh Sameer17,Buie Nicole18,Weeman Kisa19,Shine Kristin20,Haut Mitchell21,Edwards Joan21,Bastola Shyamal22,Wickham Karen22,Khanduja Karamjit S.23,Zacks Rosemary24,Pritchard Colin C.25,Shirts Brian H.25,Jacobson Angela25,Allen Brian26,de la Chapelle Albert7,Hampel Heather1,

Affiliation:

1. The Ohio State University Comprehensive Cancer Center, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus

2. Department of Pathology, The Ohio State University Wexner Medical Center, Columbus

3. The Ohio State University Comprehensive Cancer Center, Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus

4. Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, New York

5. Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus

6. Department of Surgery, The Ohio State University Wexner Medical Center, Columbus

7. The Ohio State University Comprehensive Cancer Center, Department of Cancer Biology and Genetics, The Ohio State University Wexner Medical Center, Columbus

8. Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio

9. Department of Digestive Diseases and Surgery, Cleveland Clinic, Cleveland, Ohio

10. Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio

11. Cancer Center Research, The Christ Hospital Health Network, Cincinnati, Ohio

12. TriHealth Cancer Institute, Good Samaritan Hospital, Cincinnati, Ohio

13. Columbus Oncology and Hematology Associates, Columbus, Ohio

14. Department of Cancer Services, Riverside Methodist Hospital, Columbus, Ohio

15. Department of Medicine, MetroHealth Medical Center, Cleveland, Ohio

16. Research Institute, MetroHealth Medical Center, Cleveland, Ohio

17. Department of Internal Medicine, Summa Cancer Institute, Summa Akron City Hospital, Akron, Ohio

18. Summa Center for Clinical Trials, Summa Akron City Hospital, Akron, Ohio

19. Department of Hematology/Oncology, Aultman Hospital, Canton, Ohio

20. Department of Oncology Clinical Trials, Aultman Hospital, Canton, Ohio

21. Mercy Medical Center, Canton, Ohio

22. Department of Oncology and Hematology, Genesis HealthCare System, Zanesville, Ohio

23. Division of Colon and Rectal Surgery, Mount Carmel East Hospital, Columbus, Ohio

24. Department of Clinical Trials, Mount Carmel East Hospital, Columbus, Ohio

25. Department of Laboratory Medicine, University of Washington, Seattle

26. Myriad Genetics Inc, Salt Lake City, Utah

Publisher

American Medical Association (AMA)

Subject

Oncology,Cancer Research

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