GLP-1 Receptor Agonists and Colorectal Cancer Risk in Drug-Naive Patients With Type 2 Diabetes, With and Without Overweight/Obesity

Author:

Wang Lindsey1,Wang William1,Kaelber David C.2,Xu Rong34,Berger Nathan A.14

Affiliation:

1. Center for Science, Health, and Society, Case Western Reserve University School of Medicine, Cleveland, Ohio

2. Departments of Internal Medicine, Pediatrics, and Population and Quantitative Health Sciences and the Center for Clinical Informatics Research and Education, The MetroHealth System, Cleveland, Ohio

3. Center for Artificial Intelligence in Drug Discovery, Case Western Reserve University School of Medicine, Cleveland, Ohio

4. Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio

Abstract

This cohort study compares glucagon-like peptide 1 receptor agonists (GLP-1RAs) with 7 non–GLP-1RA antidiabetics among drug-naive patients with type 2 diabetes.

Publisher

American Medical Association (AMA)

Subject

Oncology,Cancer Research

Reference6 articles.

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2. The influence of glucose-lowering therapies on cancer risk in type 2 diabetes.;Currie;Diabetologia,2009

3. Breakthrough SARS-CoV-2 infections, hospitalizations, and mortality in vaccinated patients with cancer in the US between December 2020 and November 2021.;Wang;JAMA Oncol,2022

4. Time trend and association of early-onset colorectal cancer with diverticular disease in the United States: 2010-2021.;Wang;Cancers (Basel),2022

5. Colorectal cancer risk factors. American Cancer Society. Accessed September 14, 2023. https://www.cancer.org/cancer/types/colon-rectal-cancer/causes-risks-prevention/risk-factors.html

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