Author:
AERTS L.,VAN ASSCHE F. A.,FAURE A.,SUTTER-DUB M. TH.
Abstract
The effects of progesterone and/or oestradiol treatment on the ultrastructural appearance of the pancreatic B cells has been studied in ovariectomized Wistar rats. A morphometric examination of the numerical density of dark and light granules in the B cells was therefore performed in each group of experimental rats as well as in control (olive oil-injected) rats.
In the oestradiol-treated rats, and especially in the rats with combined oestradiol/progesterone treatment, the proportions of light and dark granules in the pancreatic B cells changed, compared with control values, in favour of the light granules. This increase in light granule content was comparable to changes in B cells during pregnancy and it is suggested that the secretory activity of the B cells increases during pregnancy in a manner similar to that seen during oestradiol treatment.
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Cited by
21 articles.
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