Effects of maternal and child factors on the immunological composition of human milk

Author:

Tomaszewska Agata1ORCID,Królikowska Katarzyna1,Jeleniewska Alicja1,Porębska Klaudia2ORCID,Aleksandrowicz Karolina2ORCID,Lipińska-Opałka Agnieszka1ORCID,Rustecka Agnieszka1ORCID,Zdanowski Robert2ORCID,Kociszewska-Najman Bożena3ORCID,Kalicki Bolesław1ORCID

Affiliation:

1. Department of Paediatrics, Paediatric Nephrology and Allergology, Military Institute of Medicine – National Research Institute, Warsaw, Poland

2. Laboratory of Molecular Oncology and Innovative Therapies, Military Institute of Medicine – National Research Institute, Warsaw, Poland

3. Department of Neonatology and Rare Diseases, Warsaw Medical University, Warsaw, Poland

Abstract

Introduction and objective: The relationship between the bioactive components of milk and maternal and child health is not well elucidated yet. The aim of this study was to determine whether maternal factors (diseases and drugs used during pregnancy, method of delivery, age) and child characteristics (age, length and body weight at birth) affect breast milk composition (leukocytes, stem cells, and epithelial cells). Materials and methods: Twenty-three breastfeeding mothers of infants aged 1–6 months were recruited for the study. All the mothers and children were healthy, with no symptoms of respiratory tract infection. Samples of breast milk (20 mL) were collected. Each sample was assessed for its cellular composition (epithelial cells, mesenchymal stem cells, leukocytes). Only a few studies available in the literature have evaluated both immune cells (leukocytes) and cells of non-immune origin (mesenchymal and epithelial cells) in human milk. In this regard, our analysis is innovative. Results: Women receiving pharmacotherapy during pregnancy had a significantly higher percentage of eosinophils in their breast milk compared to women who did not receive any medication when pregnant. The cellular composition of milk correlated inversely with the age of the mother and child. The more advanced the mother’s age, the lower the number of monocytes in the milk. On the other hand, the older the child, the lower CD4 lymphocyte count in milk. Conclusions: The study suggests that the cellular composition of breast milk is influenced not only by the characteristics related to the mother but also by child-depended factors. Research in this area needs to be continued.

Funder

Wojskowy Instytut Medyczny

Publisher

Medical Communications Sp. z.o.o.

Subject

Family Practice,Pediatrics, Perinatology and Child Health

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3