Effects of Paracetamol on the Development of Zebrafish (Danio rerio)

Abstract

The misuse of paracetamol is becoming more prevalent worldwide. Due to non-compliance with recommended dosage and regulations, paracetamol consumption can result in serious health issues such as liver necrosis, kidney damage, heart damage, and hematological changes. This study sought to investigate the impact of paracetamol on the development of zebrafish embryos, which are often used as a model for assessing the effect of drug exposure on animals. The results indicated that paracetamol negatively affects the hatching and survival rates of zebrafish. Additionally, paracetamol exposure caused spinal abnormalities, pericardial edema, hypopigmentation, reduced heart rate, and spontaneous movement in zebrafish larvae. The developmental abnormalities in zebrafish were more significant with higher concentrations and longer exposure times. These findings may provide valuable insights into the detrimental impact of paracetamol on aquatic animals.