Author:
Khan Asif,Muhamad Nur Airina,Taha Rosna Mat,Mohamad Jamaludin,Al-Shara Baker
Abstract
Crocus sativus L., a medicinally important species of the Iridaceae family which produces the herb saffron, plays an effective role in combating various pathogenic disorders including cancers and cardiovascular diseases. Apart from its conventional colorant and aroma-inducing attributes, various phytochemical compounds associated with saffron are now being intensively studied. More than 300 phytochemical compounds, derived from saffron stigmas alone, belong to various classes of secondary metabolites such as carotenoids, terpenoids, flavonoids, and anthocyanins; and they have immense therapeutic applications. Furthermore, pharmacogenomic studies of saffron extracts have revealed promising biocompatible and anticancer potentials against various drug-resistant cell lines which reduce cellular division and proliferation of malignant cells. Keeping in view with the numerous pharmacological properties associated with saffron, the present review explicitly discusses the role of its elemental contents in the prevention and treatment of various cancers and cardiovascular ailments.
Publisher
Universiti Putra Malaysia
Reference120 articles.
1. Abedimanesh, N., Motlagh, B., Abedimanesh, S., Bathaie, S. Z., Separham, A. and Ostadrahimi, A. 2020. Effects of crocin and saffron aqueous extract on gene expression of SIRT1, AMPK, LOX1, NF-κB, and MCP-1 in patients with coronary artery disease: a randomized placebo-controlled clinical trial. Phytotherapy Research 34(5): 1114-1122.
2. Aier, I., Semwal, R., Sharma, A. and Varadwaj, P. K. 2019. A systematic assessment of statistics, risk factors, and underlying features involved in pancreatic cancer. Cancer Epidemiology 58: 104-110.
3. Akbar, S. 2020. Handbook of 200 medicinal plants. United States: Springer.
4. Aleali, A. M., Amani, R., Shahbazian, H., Namjooyan, F., Latifi, S. M. and Cheraghian, B. 2019. The effect of hydroalcoholic saffron (Crocus sativus L.) extract on fasting plasma glucose, HbA1c, lipid profile, liver, and renal function tests in patients with type 2 diabetes mellitus: a randomized double-blind clinical trial. Phytotherapy Research 33(6): 1648-1657.
5. Alizadeh, F. and Bolhassani, A. 2015. In vitro cytotoxicity of Iranian saffron and two main components as a potential anti-cancer drug. SM Journal of Pharmacology and Therapeutics 1(1): article no. 1001.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献